I have been prescribed by a certain Belgian Dr. two I.M. injections of 10ml hydrocobalamin (B12) x2/week.
I have been too sick to make it to these appointments at my nurses office every week.
I have been taking sub lingual tablets instead, is there a difference, is this as good?
what kind of b12 do you take?
Cyanocobalamin is the standard B-12 you find in most pharmacies and what most physicians prescribe. I usually recommend a sublingual methylcobalamin as more people may respond to it vs the regular B-12. For the poor methylators, their genetics dictate that Adenosylcobalamin and Hydroxocobalamin be utilized. People that have a MTRR mutation (most of us here do) often need more cobalamin to complete the folate pathway. Adenosylcobalamin is utilized like methylcobalamin and beneficial for the poor methylators. Care should be taken with Hydroxocobalamin in that lower quantities are often needed and it still needs converting to methylcobalamin. It has a higher chance of binding transport proteins than the other forms. Either get frequent blood work to determine B-12 levels while taking it or pause administration when adverse events happen.
Methylcobalamin and adenosylcobalamin are active enzymes that work intracellularly to ensure specific reactions take place. The cyanocobalamin and hydroxocobalamin are usually serum laden and act as transports for the cobalamin molecules.
B-12 insufficiency is just one potential problem that we sick people face. The entire methylation pathway needs to be looked at and the deficiencies need to be discovered. What many will find is that there are inefficiencies in sulfur metabolism and sulfur containing amino acids like methionine can be problematic. This begins in the GI tract and dysbiosis is very common.