Feeling depressed after glutathione injection

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vacant
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Date Joined Oct 2012
Total Posts : 132
   Posted 1/18/2018 11:25 AM (GMT -6)   
Hi,
Does anybody feels tired and depressed after glutathione injection...today is my first day and, I feel bad.

Thank you

PeteZa
Veteran Member


Date Joined Jul 2015
Total Posts : 9729
   Posted 1/18/2018 11:30 AM (GMT -6)   
I have never done this and I have not heard of side effects either.

Hopefully someone will come along that knows more than I do.

Traveler
Elite Member


Date Joined May 2007
Total Posts : 36310
   Posted 1/18/2018 12:32 PM (GMT -6)   
It's quite possible it's part of a herx for you. Glutathione is a really good detoxing agent, so it could literally release more toxins than your body can adequately handle/remove without causing symptoms to increase, or for some new ones to pop up.

I would encourage you to increase your detoxing and concentrate on self care today, and hopefully this is very short lived for you.
Herb only treatment for Lyme & Bart ended 12/11 - no active symptoms for 2 yrs -Herb only treatment for Babesia ended 12/12
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Had Lyme, Bart, Babs, RMSF, Ehrlichia, Myco, Anaplasmosis, EBV
New set of infections 8/2014 - still treating.
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Connor77
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Date Joined Jul 2016
Total Posts : 523
   Posted 1/18/2018 4:58 PM (GMT -6)   
I have a lot of experience with this and research background.

If the depressed feeling lasts for a few days then it's unlikely a herx. Glutathione gets used up quickly in the body. However, the detox process that glutathione uses relies on methyl-b12 and methyl-folate. If you are low in either of these, then increasing glutathione will deplete your B vitamin stores faster.

If you have MTHFR, MTRR, or MTR mutations in your genetics, then glutathione will make you feel worse, not better.

If you have access to them, try taking 1mg (1000mcg) Methyl-B12 and 1000mcg Methyl-folate. If they're sublingual then you must hold them in your mouth for at least 40 minutes for them to work. The best place is to put them is between your upper lip and gums. If you chew and swallow them, it won't work.

If you have MeB12 injections, take 1000mcg and then take the same amount of methyl-folate by mouth. If they aren't the methyl forms then they won't fix your depleted status.

If you feel better within hours of taking these, then your problem is that your body probably has the common genetic mutations in the methylation cycle or detox pathways and glutathione is burdening your body.

TL;DR version -- you're likely experiencing a deficiency state and glutathione makes you more deficient.

cakegirl
Regular Member


Date Joined Nov 2016
Total Posts : 262
   Posted 1/18/2018 5:05 PM (GMT -6)   
I've read that glutathione shouldn't be taken if you have amalgam fillings because it can mobilize mercury.

Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 33876
   Posted 1/18/2018 11:23 PM (GMT -6)   
Connor - The sublingual tabs can be put under the tongue - and mine are dissolved quicker than 40 minutes.

A herx can last longer than a few days...if we're not detoxing well.
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
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goshawk
Forum Moderator


Date Joined Sep 2016
Total Posts : 2299
   Posted 1/19/2018 5:47 AM (GMT -6)   
Hope you feeling better today, take care Jo

WalkingbyFaith
Veteran Member


Date Joined Aug 2017
Total Posts : 2023
   Posted 1/19/2018 9:43 AM (GMT -6)   
Connor77 said...
I have a lot of experience with this and research background.

If the depressed feeling lasts for a few days then it's unlikely a herx. Glutathione gets used up quickly in the body. However, the detox process that glutathione uses relies on methyl-b12 and methyl-folate. If you are low in either of these, then increasing glutathione will deplete your B vitamin stores faster.

If you have MTHFR, MTRR, or MTR mutations in your genetics, then glutathione will make you feel worse, not better.

If you have access to them, try taking 1mg (1000mcg) Methyl-B12 and 1000mcg Methyl-folate. If they're sublingual then you must hold them in your mouth for at least 40 minutes for them to work. The best place is to put them is between your upper lip and gums. If you chew and swallow them, it won't work.

If you have MeB12 injections, take 1000mcg and then take the same amount of methyl-folate by mouth. If they aren't the methyl forms then they won't fix your depleted status.

If you feel better within hours of taking these, then your problem is that your body probably has the common genetic mutations in the methylation cycle or detox pathways and glutathione is burdening your body.

TL;DR version -- you're likely experiencing a deficiency state and glutathione makes you more deficient.


Connor,

Thank you for this info. I very likely have this issue. My doc put me on liposomal glutathione in Sep 2016. I've taken it daily ever since. I have some problems with it. It often makes me feel worse, and there were many times I felt like my body was dumping toxins after taking it, as I would have to urinate soon after and would feel some pain with urination. I also suspect it's pulling mercury or other heavy metals as I increasingly feel like that is happening, too, but I'm afraid to stop taking it. I'm very toxic and an extremely poor detoxes.

I would love to test the B-12 and folate you mentioned, but I've been afraid of B-12 and multivitamins for years. I had allergy patch testing done in 2009 and tested positive for cobalt and chromium. B-12 has cobalt and multivitamins have both. I don't know if they would cause problems for me in reality or not. I did take cheap multivitamins years ago and never noticed anything, but I'm sure I could potentially cause inflammation or damage without any obvious reactions. I've looked at these in the store, but chickened out when I realized all the B vitamins were in the form of saccromyces cerevisea (bakers yeast). Also they're all in megadoses. Do you know of any brands that are not yeast based and are in low doses that might be safe for me to test?

My B-12 was tested in Sep 2016, and it was at low end of normal in the 200's range. If glutathione reduces B-12, I wonder what mine is now?!!!

Traveler
Elite Member


Date Joined May 2007
Total Posts : 36310
   Posted 1/19/2018 2:08 PM (GMT -6)   
WalkingByFaith,
I would encourage you to start a new thread asking members for any suggestions on B-12 with a cobalt allergy. This post may not be seen by those that may know.

Obviously, either way, you will need a lot of testing, so be sure that you have a doctor that will work with you on this.
Herb only treatment for Lyme & Bart ended 12/11 - no active symptoms for 2 yrs -Herb only treatment for Babesia ended 12/12
www.healingwell.com/community/default.aspx?f=30&m=2977364
Had Lyme, Bart, Babs, RMSF, Ehrlichia, Myco, Anaplasmosis, EBV
New set of infections 8/2014 - still treating.
Come visit me: dogwoodtraditionals.freeforums.net/
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