I've not had the adrenal surges. I did have a bad flu/cold just before the holidays. It is so dry by me this winter, that I started a humidifier right by me (whereever I was) in addition to the one on the furnace. I also stopped taking meds/herbs for a few days. I also increased Vitamin A for those few days.
I would increase your fluids and add the humidifier. Do you have a doctor that can run bloodwork for you?
MTHTR single mutation; Positive Igenix IgG Jan 2017; March/Apr '17: doxy, Tinizadole. 5/1 samento and mino/tini. 5/28- back to doxy, added activated charcoal. 6/9 - stopped antibiox; staying with samento, red root and houttiya and supps. tried LDN; 8/24 rifampin, samento, red root and supps. On and off rifampin. 1/1/18 - 1/20 rifampin. Herbs and vitamins only now.