The winter by has been incredibly dry. Even our dogs paw pads have cracks! So maybe try a humidifier or, my mom's trick, vaseline in the nose first. Even breathing boiling water can help. Steam showers.
With a neti pot, you can reduce the amount of salt. Saline has pretty low content I think, but if you have any cracks or sensitivity from dryness I think that would cause some discomfort.
MTHTR single mutation; Positive Igenix IgG Jan 2017; March/Apr '17: doxy, Tinizadole. 5/1 samento and mino/tini. 5/28- back to doxy, added activated charcoal. 6/9 - stopped antibiox; staying with samento, red root and houttiya and supps. tried LDN; 8/24 rifampin, samento, red root and supps. On and off rifampin. 1/1/18 - 1/20 rifampin. Herbs and vitamins only now.