Mycoplasma Pneumoniae Antibodies (IGG,IGM) - IGG high/IGM normal - what does this result mean?

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1000Daisies
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Date Joined Apr 2016
Total Posts : 2474
   Posted 2/5/2018 12:59 PM (GMT -6)   
So, does this basically mean he had a prior infection and it's unknown whether it's a current infection/problem?

If I retest at a future date and he's doing better with this, will that mean his IGG number will decrease to normal? In other words, is it even worth retesting at a future date to check on progress?
(I read previously about people's mycoplasma numbers coming down. Is it this number or a different number?)

Any insight is appreciated. We don't normally test for this (first time testing for this).

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MYCOPLASMA PNEUMONIAE ANTIBODIES (IGG,IGM)

-MYCOPLASMA PNEUMONIAE ANTIBODY (IGG)
VALUE= 3.29 H (high)
NOTES on 'MYCOPLASMA PNEUMONIAE ANTIBODY (IGG):
Reference Range
Negative: < or = 0.90
Equivocal: 0.91-1.09
Positive: > or = 1.10

-MYCOPLASMA PNEUMONIAE ANTIBODY (IGM)
VALUE: <770
NOTES on 'MYCOPLASMA PNEUMONIAE ANTIBODY (IGM):
Reference Range
Negative: <770
Low Positive: 770-950
Positive: >950

A positive IgM antibody result with or without a positive IgG antibody result, is consistent with recent infection. However, a negative result does not necessarily rule out recent infection as some individuals may not mount another IgM response, if previously infected. A positive IgG antibody result, in the absence of a positive IgM antibody result, indicates that the patient has antibody to Mycoplasma. It does not differentiate between an active or past infection. The clinical diagnosis must be interpreted in conjunction with the clinical signs and symptoms of the patient.

Traveler
Elite Member


Date Joined May 2007
Total Posts : 36310
   Posted 2/5/2018 2:57 PM (GMT -6)   
I wish I knew more about the testing, 1000Daisies! But at least this will bump your post back up to the top of the page.
Herb only treatment for Lyme & Bart ended 12/11 - no active symptoms for 2 yrs -Herb only treatment for Babesia ended 12/12
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Had Lyme, Bart, Babs, RMSF, Ehrlichia, Myco, Anaplasmosis, EBV
New set of infections 8/2014 - still treating.
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yancync
Veteran Member


Date Joined Nov 2015
Total Posts : 551
   Posted 2/5/2018 3:24 PM (GMT -6)   
Hi!

Well, we've been dealing with myco for years - so stubborn an it's still a mystery to me. It's DS's last infection to clear and it seems to wax and wane. He finally got his first recent negative test last month and then this month it went back up - UGH. He was also negative last fall and then either got reinfected or relapsed.

So, initially they tested for both Igg and Igm and then about every 3 months they would test again - and it would still be high. Now they are testing monthly and only for Igm not Igg anymore. Igg is past evidence and Igm is current I believe.

From Mayo online: Positive IgM results are consistent with recent infection, although false-positives may occur (see Cautions).

A single positive IgG result only indicates previous immunologic exposure.

From LabTestsOnline.org

Antibody testing
Significant concentrations of M. pneumoniae IgM and/or a four-fold increase in IgG levels between the initial sample and the convalescent sample indicate an active or recent M. pneumoniae infection. Increases in IgG, without IgM, can also be seen with a re-infection.

If neither IgM or IgG are present in detectable concentrations, then it means that a person being tested either does not have an active infection, has not had a mycoplasma infection (recent or in the past), or that the person's immune system has not produced antibodies in response to the microorganism.

Hope this helps a bit.
Parent of teen DS w/ CDC+ Lyme test Nov 2015, late stage Lyme + mycoplasma, bartonella, babesia. Currently treating with antibiotics/anti-malerials, multivitamin, magnesium, Charlotte's Web Advanced CBD oil.

Website I started: ParentsofLymeKids.com aka Lyme Disease 101 for Parents

Kaitlan
Regular Member


Date Joined Mar 2017
Total Posts : 66
   Posted 2/5/2018 11:45 PM (GMT -6)   
-1000 Daisies

From my understanding IgMs are produced when an infection is brand new to the immune system. After the immune system has a memory of the the infection it makes IgGs. So if it's an infection that's many years old that has reactivated, it wouldn't produce IgMs, because it produced IgMs years ago when the infection was brand new. Now the immune system has a memory of the infection so if it reactivates it will produce IgGs to try to fight it. IgGs without IgMs doesn't mean not active, it just means not brand new.
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