My science based Anti inflammatory/cytokine protocol that has really helped me

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Lapis_29
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Date Joined Sep 2017
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   Posted 2/8/2018 11:18 AM (GMT -6)   
I did a lot of research on inflammation and found what actually reduces inflammation in the body and leads to lower cytokine levels.

I started this protocol about 6 weeks ago and have felt a dramatic lowering of inflammation in my joints and throughout my whole body.

Here it is.

Note: Quercetin MUST be mixed with fat, as its active properites are lipid soluble. If you take Q caps with tea / water it is useless

Nettles MUST be freeze dried, anything else is useless

Morning

Blueberries (thawed frozen) with full fat yogurt, a spoonful of Quercetin powder, spoonful of royal jelly all mixed together. Take the following capsules with this, I take 2- 3 caps of each, 4 or 5 of SOD, 5 -6 bioflavonoids

Curcumin (with piperine)
Boswelia
Grapes seed extr
Nettles
Ginger
SOD
Elderberry extr
Gingko
EGCG
Bioflavanoids
PQQ
Co Q 10

Lunch/dinner

A heaping frying pan full of Leafy greens + Olive Oil (PUFA) with hot sauce, very lightly heated up. I take 3 caps DHA, 7 gr Vit C and 2 caps lysine with this for heart health.

The combination of the nitrates in the greens and the unsaturated fatty acids in the olive oil create something called nitro fatty acid. These fatty acids reduce blood pressure and reduce inflammatory cytokines throughout the entire body. Great for the heart. This is a new discovery, ground breaking research and its the key as to why the Medditeranian diet is so good for the heart.

The olive oil should be soaked into the greens, don’t just eat them around the same time. Try heating the greens up, just a bit, this allow you to eat a greater quantity of greens. Eat LOTS of this, its really fantastic for you on so many levels. Get real olive oil, most olive oil in stores is fake.

I pretty much only eat wild caught salmon now for meat. Nearly All meat products encourage inflammation, salmon and other omega 3 rich fish are anti inflammatory. Frying the fish at high temps destroys its anti inflamm properties, cook at low temps.

No chips or anything with heated up fat, deep fried etc. Oxidized fat is VERY inflammatory producing.

No soda, no sugar, no cake, no cookies. Etc.

For a sweet snack I eat high quality chocolate wich is rich in polyphenols

This first study is really great. If you scroll down to Table one and click on that, it lists various compounds and the specific cytokines those compounds reduce. Very helpful.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877453/

http://www.lifeextension.com/Magazine/2017/1/PQQ-Reduces-Arthritis-Inflammation/Page-01

https://www.worldhealth.net/news/elderberry-eases-inflammation/

https://www.ncbi.nlm.nih.gov/pubmed/10606356

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527648/

https://www.ncbi.nlm.nih.gov/pubmed/16887803

https://academic.oup.com/nutritionreviews/article-abstract/73/6/348/1845798?redirectedFrom=PDF

https://www.ncbi.nlm.nih.gov/pubmed/16887803

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011108/

Lapis_29
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Date Joined Sep 2017
Total Posts : 845
   Posted 2/8/2018 11:34 AM (GMT -6)   
Somebody said...


“When unsaturated fatty acids, found in olive, nuts, and fish oils, are eaten together with a source of nitrate or nitrite, found in vegetables such as beetroot and those with green leaves, they form nitro fatty acids in the body,” said lead researcher of the study Philip Eaton, a professor of cardiovascular biochemistry at Kings College London, according to HealthDay.

Eaton’s team found that these nitro fatty acids were able to inhibit the enzyme soluble epoxide hydrolase (sEH), which can affect lipid metabolism — studies have shown people with obesity and metabolic dysfunction have increased levels of sEH. By connecting to sEH, the nitro fatty acids are able to set off a chain of reactions that result in the dilation of blood vessels, Medical News Today reported. Thus, blood pressure lowers.

They came to this conclusion after testing a group of normal and genetically engineered mice, the latter of which were altered with sEH unable to bind to nitro fatty acids. The mice were then given a hormone to induce high blood pressure, and fed either components of the Mediterranean diet or nitro fatty acid supplements. After eating, only the normal mice’s blood pressure went down.

“The findings of our study help to explain why previous research has shown that a Mediterranean diet supplemented with extra-virgin olive oil or nuts can reduce the incidence of cardiovascular problems like stroke, heart failure, and heart attacks,” Eaton said in a press release.

astroman
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Date Joined Mar 2014
Total Posts : 4880
   Posted 2/8/2018 12:34 PM (GMT -6)   
Good you found some relief. We are what we eat. Genes/ individual food sensitivities obviously effect outcome too.

Did you bother to compare tested cytokine levels before and after your "project"?

Alcohol- is poison, thats why you get a buzz.

Related note: A buddies fitness fanatic wife finally opened up that she became alcohol dependent. A glass of wine a day (mamas little helper) got out of control. Her words :"the most fittest drunk around".

I'm addicted to napping.

Lapis_29
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Date Joined Sep 2017
Total Posts : 845
   Posted 2/8/2018 3:36 PM (GMT -6)   
no, I dont have the coverage or money to do lots of testing, wish i had.

Missouri
Regular Member


Date Joined Sep 2017
Total Posts : 337
   Posted 2/8/2018 4:39 PM (GMT -6)   
Hi Lapis. I always enjoy your posts and have wondered about your history with Lyme and co. How long have you been treating? Is the protocol you listed in this post the only you have been doing the past 6 weeks? How long have you been dealing with Lyme? How much have you recovered?

If you have time to indulge my curiosities smile

-M

Lapis_29
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Date Joined Sep 2017
Total Posts : 845
   Posted 2/8/2018 6:10 PM (GMT -6)   
Missouri said...
Hi Lapis. I always enjoy your posts and have wondered about your history with Lyme and co. How long have you been treating? Is the protocol you listed in this post the only you have been doing the past 6 weeks? How long have you been dealing with Lyme? How much have you recovered?

If you have time to indulge my curiosities smile

-M


I likely got lyme in the early 80's, long before anyone anywhere knew you could get chronic lyme. we went camping in the great white north regularly and had many tic bites. It manifested as CFS for most of my adult life, but I still had a somewhat normal life.

then about 15 years ago things started going downhilll with lots of neurological issues, docs had no clue what was wrong, many many many many many tests etc, no one could figure it out. serious muscle wasting and extreme joint pain, muscle weakness in limbs, loss of function, brain fog, etc. I am currently on VA disability.

finally got my lyme diagnosis about 4 years ago. since then have been trying different things, with rife being the one thing that has helped the most. I am better than I was but still have a very long way to go.

yes, I only have done this protocol the last 6 weeks (and also rife but i have been doing that for over a year now). So I am confident this protocol is working for me and will continue it.

Missouri
Regular Member


Date Joined Sep 2017
Total Posts : 337
   Posted 2/8/2018 9:49 PM (GMT -6)   
How did you discover it was tick borne infections? Did you remember a bulls-eye on a camping trip or did you have positive tests?

Lapis_29
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Date Joined Sep 2017
Total Posts : 845
   Posted 2/8/2018 11:06 PM (GMT -6)   
clinical diagnosis

also I respond to lyme DNA specific rife frequencies

I remember at least 1 bullseye, didn't even know what that meant back then

Eiren
Regular Member


Date Joined Aug 2017
Total Posts : 58
   Posted 2/9/2018 2:40 AM (GMT -6)   
Curious about a few things in your protocol.

Why the blueberries? I know they're healthy, but I can't find out if they have any nitrates. The highest nitrate level in fruit seems to be strawberries, but it's still not much.

I have some beet powder that I mix into my morning yogurt, makes it look pink and the taste is masked by the yogurt and the vanilla whey powder I stick in there, too. Topped with seeds and nuts. I don't have royal jelly, but I put some bee pollen on there as well. Hey, I was onto something!

Greens with EVOO. Simple and healthy. Spinach is high in nitrate, but has the downside of also be high in oxalate. Arugula seems like a good choice, but can be pricey. Celery is high in nitrate, but as it is mostly water you have to eat a lot of it. I've heard of bodybuilders doing the "hack" of buying celery powder from the grocery store as a cheap NO boost. Maybe celery powder on a spoonful of EVOO would be a quick substitute if you're sick of salad?

The supplements you take are anti-inflammatories, and separate from the nitro fatty acids formation, yes? Or do you think having it all together is synergistic in some way? I already have some of the things you list, yeah, and more the better, but $$$ is the thing (unfortunately).

Ooh, nettle is also high in nitrates. I have stinging nettle growing around my house as a crazy weed (I live in Europe). In a few months I can fry them up and pour EVOO over them. Nearly free health supplement, yes?

Oh, and do you take the 7g of C all at once? I read somewhere that the body can only process a bit at a time, so you need to supplement throughout the day for max absorption of high levels. But wondering if there was a different reasoning behind your method.

Georgia Hunter
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Date Joined May 2012
Total Posts : 2116
   Posted 2/9/2018 4:30 AM (GMT -6)   
Always good to read your posts Lapis. What you are doing is increasing the depleted nutritional items your body is deficient of. Long periods of chronic inflammation will do that to you.

It would take too long to go into everything you are doing, but a couple of things flashed when I read your post. You have increased your saponin intake and these chemicals from plants have been used as anti-parasitic and anti-fungal agents by primitive cultures for centuries. You have increased your sulforaphane intake which helps eliminate electrophiles. This reduces oxidative stress as much or more than anything.

Eating a lot of spinach can possibly increase forms of glucosinolate which increases available proteins like tryptophan and methionine. It basically frees them up to use in vital pathways. Ironically, glucosinolates act as pesticides for the plants to protect themselves.

Many of your supplements have antiviral or anti-plasmodial properties. The bioflavinoids are important for increasing pterin and polyphenol levels. Many people in our condition have this problem and this allows for more BH4 production.

You are also increasing caratenoids, lutein, B-carotene, ascorbic acid, Mg, Ca, K, Fe, and zeaxanthin. We would all function better if we did as you are doing.

One thing possibly overlooked is that you have reduced animal protein intake. This has a huge affect on inflammation.

Congrats on finding a way to get better though a lot of hard work.

Lapis_29
Veteran Member


Date Joined Sep 2017
Total Posts : 845
   Posted 2/9/2018 8:32 AM (GMT -6)   
Eiren said...
Curious about a few things in your protocol.

Why the blueberries? I know they're healthy, but I can't find out if they have any nitrates. The highest nitrate level in fruit seems to be strawberries, but it's still not much.
.


blueberries truly are a super food, so many benefits. here is a study which shows it normalize inflammation associated with PTSD in the brain

/www.ncbi.nlm.nih.gov/pubmed/27603014

the leafy greens are the major source of nitrates, plenty of nitrates there, no need to look for them elsewhere as long as you get plenty of fresh leafy greens. I buy spring mix so i get a nice mix of different greens.

Lapis_29
Veteran Member


Date Joined Sep 2017
Total Posts : 845
   Posted 2/9/2018 8:36 AM (GMT -6)   
Eiren said...


The supplements you take are anti-inflammatories, and separate from the nitro fatty acids formation, yes? Or do you think having it all together is synergistic in some way? I already have some of the things you list, yeah, and more the better, but $$$ is the thing (unfortunately).

Ooh, nettle is also high in nitrates. I have stinging nettle growing around my house as a crazy weed (I live in Europe). In a few months I can fry them up and pour EVOO over them. Nearly free health supplement, yes?

Oh, and do you take the 7g of C all at once? I read somewhere that the body can only process a bit at a time, so you need to supplement throughout the day for max absorption of high levels. But wondering if there was a different reasoning behind your method.


yes, the supplements and the nitro fatty acid protocols are separate although both are anti inflammatory as well as other benefits.

yes! fresh harvested nettles are awesome. eat as much as you like. they make a great broth base for soup, super rich in minerals.

probably better to take the vit C throughout the day, but sometimes it just doesn't work out.

Lapis_29
Veteran Member


Date Joined Sep 2017
Total Posts : 845
   Posted 2/9/2018 8:44 AM (GMT -6)   
Georgia hunter, thank you! very valuable feedback, appreciate it

Lapis_29
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Date Joined Sep 2017
Total Posts : 845
   Posted 2/9/2018 2:56 PM (GMT -6)   
You can substitute conjugated linoleic acid (CLA) instead of olive oil if you like. CLA is actually superior to olive oil in forming the anti inflammatory nitro fatty acid. You can get CLA supplements on amazon or wherever. Take 1-3 caps when eating your leafy greens.

Somebody said...


For some time, there have been papers published on the anti-inflammatory and vasorelaxation activity of nitrated fatty acids.1–4 Now, a new paper5 reports that “conjugated linoleic acid (CLA) is the preferential unsaturated fatty acid substrate for nitration reactions during oxidative conditions and digestion.” It is reported that “multiple enzymatic and cellular mechanisms account for CLA nitration, including reactions catalyzed by mitochondria, activated macrophages, and gastric acidification.”5 It is reported here that CLA yields up to 105 greater extent of nitration products as compared to it’s natural competitor bis-allylic linoleic acid.

The nitrated fatty acids act as a circulating reservoir of nitrite for local conversion to nitric oxide. Hence, it is a way to increase nitric oxide availability throughout the body.

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