When treating lyme with neuro symptoms, one could use a combination of Rocephin and a macrolide. However, there is some research indicating that combining a bactericidal (Rocephin) and bacteriostatic (macrolide) antibiotic may result in some antagonism between the two drugs. The reasoning is that Rocephin works best when the spirochetes are actively dividing, and a macrolide would stop the spirochetes from dividing. What do you think, is this a concern, and if so, can it still be useful to combine these two (I assume so, because the combination is used, but would like to double-check)? Would also the effect of the macrolide be affected by this combination in some way?
Is it better to just add a tetracycline to the macrolide?