Rocephin and macrolide in combination for Lyme?

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New Member

Date Joined Feb 2018
Total Posts : 2
   Posted 2/10/2018 8:20 AM (GMT -6)   

When treating lyme with neuro symptoms, one could use a combination of Rocephin and a macrolide. However, there is some research indicating that combining a bactericidal (Rocephin) and bacteriostatic (macrolide) antibiotic may result in some antagonism between the two drugs. The reasoning is that Rocephin works best when the spirochetes are actively dividing, and a macrolide would stop the spirochetes from dividing. What do you think, is this a concern, and if so, can it still be useful to combine these two (I assume so, because the combination is used, but would like to double-check)? Would also the effect of the macrolide be affected by this combination in some way?

Is it better to just add a tetracycline to the macrolide?

Veteran Member

Date Joined Jun 2017
Total Posts : 518
   Posted 2/10/2018 9:27 AM (GMT -6)   
Hi! Good question! I don't know the answer, but I wanted to welcome you in the meantime, until someone comes along with info about that combination. Welcome to the forum!
"This too shall pass. It might pass like a kidney stone, but it will pass."
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