Alternative to IV Rocephin when there is no strong meningitis inflammation?

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Yosemite
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Date Joined Feb 2018
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   Posted 2/10/2018 12:30 PM (GMT -6)   
According to "http://cmr.asm.org/content/23/4/858/T1.expansion", Rocephin does not pass the blood brain barrier well unless there is strong meningitis inflammation. If you "only" have brain inflammation and not a strong meningitis, is there another beta-lactam (oral or IV) which is more suitable? Maybe Amoxicillin, Ceftin or Cefotaxime?

Thank you!

goshawk
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Date Joined Sep 2016
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   Posted 2/10/2018 5:31 PM (GMT -6)   
bumping for more views

Girlie
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Date Joined May 2014
Total Posts : 33957
   Posted 2/10/2018 6:40 PM (GMT -6)   
Yosemite said...
According to "http://cmr.asm.org/content/23/4/858/T1.expansion", Rocephin does not pass the blood brain barrier well unless there is strong meningitis inflammation. If you "only" have brain inflammation and not a strong meningitis, is there another beta-lactam (oral or IV) which is more suitable? Maybe Amoxicillin, Ceftin or Cefotaxime?

Thank you!


Well if you're interested in b/b barrier penetration - then you can cross Ceftin and Cefotaxime off the list..as they are also cephalosporins.
(It says in that study)

Minocycline is one of the best ones for b/b barrier penetration.
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi
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