High Biliruban = Gilberts Syndrome, (slow Liver Detox) gene UGT1A1, herxing, Juandace and fatigue

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astroman
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Date Joined Mar 2014
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   Posted 2/10/2018 6:52 PM (GMT -6)   
Since I have some liver gene issues in phase I and II, I tend to read up on how new supplements or medications might affect liver health (with this info, I will never drink hard again for my remaining life). Thank 23andme for showing this and other genes that explained some things to me.

FYI: Bilirubin levels in some individuals (which is known as Gilberts Syndrome), affects about 5% of adults. If you've had occurring Jaundice without acute or on going alcohol poisoning (your not a drunk), you prob have this issue. This will also cause fatigue. **And most likely will make harder hitting herxes for those with this (did in my case).**

There are several versions of a defective gene which are common in people who have this liver issue. The gene is: UGT1A1, involved in liver detox phase I.

/en.wikipedia.org/wiki/Gilbert%27s_syndrome

D-limonene helps with liver phase II methalation, I dont know if it helps detox in liver phase I methalation. Coffee, as hard as it can be on the gut, is good at speeding up a slow phase I liver. Kava brand low acid instant coffee is easy on the gut (there is no Kava plant in it, poor name choice).

*Liver Bilirubin and alt/ast are always worthwhile tests for anyone on the lyme forum and these are usually INCLUDED on a yearly physical blood test.*

If you have any version of the above mentioned gene, and take new supplements which might effect liver function or any med that effects liver (ABX), its good to do these tests.

Double copies of any poor liver function genes mean your liver is comparable to partially plugged house plumbing. If overloaded , back-ups might happen. Keep an eye on it, you only have one many of these ABX's are pretty hard on the liver too.

Post Edited (astroman) : 2/11/2018 9:53:59 AM (GMT-7)


Girlie
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Date Joined May 2014
Total Posts : 32622
   Posted 2/10/2018 7:12 PM (GMT -6)   
I was told I had Gilbert’s syndrome when I was a teenager due to elevated bilirubin

Slightly elevated bilirubin - but other LFT good.

Interestingly with Lyme treatment my other liver function tests results rose - and my LLND had me stop all abx for 2 1/2 months so they could normalize.

They all went into range INCLUDING the bilirubin and now over two years later - bilirubin still hasn’t risen.

My regular dr just shrugs her shoulders and doesn’t think it’s a big deal like I do.

She said something like: With Gilbert’s the number can go up and down.

Well - for over 30 years the bilirubin has consistently been high - not up and down - and now after Lyme treatment its consistently in range?
Makes me wonder
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

astroman
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Date Joined Mar 2014
Total Posts : 4879
   Posted 2/10/2018 8:52 PM (GMT -6)   
So your thinking ABX might have corrected your elevated Biliruban which was there before abx use? Hmm.

Are you eating healthier or did you drink alcohol more before lyme ABX?

If one has the gene, it just means its more probable for this elevation to happen.

Ive had Juandice eyes several periods in the past before I knew what this was. There's a whole bunch of possible dis-functioning liver genes. Might be why I herxed five months long too on ABX.

This is also why some drunks livers fail and some dont - its in there genes.

Girlie
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Date Joined May 2014
Total Posts : 32622
   Posted 2/10/2018 9:23 PM (GMT -6)   
astroman said...
So your thinking ABX might have corrected your elevated Biliruban which was there before abx use? Hmm.

Are you eating healthier or did you drink alcohol more before lyme ABX?

If one has the gene, it just means its more probable for this elevation to happen.

Ive had Juandice eyes several periods in the past before I knew what this was. There's a whole bunch of possible dis-functioning liver genes. Might be why I herxed five months long too on ABX.

This is also why some drunks livers fail and some dont - its in there genes.


I don’t really know - is it possible I had Lyme/Bart back then and my immune system was keeping most symptoms at bay - but not the affects on my liver? IDK why my liver would be in better shape (ie lower bilirubin) after treating Lyme disease
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

astroman
Veteran Member


Date Joined Mar 2014
Total Posts : 4879
   Posted 2/10/2018 11:26 PM (GMT -6)   
Maybe if you have one of the "Gilberts genes", its just one copy, thus waxes and wanes throughout the years.
Had initial lyme symptoms late 80's, then again and with bullseye early 90's. Ended ABX for Lyme in 2015. Rebuilding / fine tuning / fixing muscles since then; member "10 Percenters Lyme Club". What an adventure this has been. Hashimotos adds to the enjoyment.

Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 32622
   Posted 2/10/2018 11:51 PM (GMT -6)   
astroman said...
Maybe if you have one of the "Gilberts genes", its just one copy, thus waxes and wanes throughout the years.


That would make sense - except it hasn't been waxing and waning. I have had high bilirubin for over 30 years....periodically checking it, and even monthly checks while on lyme treatment. Then I take a 2 1/2 month off abx...go back on Bart treatment...and it stays good. Very strange.
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

Georgia Hunter
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Date Joined May 2012
Total Posts : 2116
   Posted 2/11/2018 2:38 AM (GMT -6)   
Why is it that it seems we are always talking about yellow substances? Atovaquone, bilirubin, and bioflavinoids are all yellow.

A lot of interesting thought can be made when looking into the topic of this thread. It is over my head so I hesitate to mention what little I know. It would scramble some brains for sure. lol
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