Garlic and Cinnamaldehyde
(the active ingredient in cinnamon bark) sterilized the B. burgdorferi stationary phase culture as shown by no regrowth during 21-day subculture.
"Lyme disease is the most common vector borne-disease in the US. While the majority of the Lyme disease patients can be cured with the standard 2-4 week antibiotic treatment, about
10-20% of patients continue to suffer from persisting symptoms. While the cause of this condition is unclear, persistent infection was proposed as one possibility. It has recently been shown that B. burgdorferi develops dormant persisters in stationary phase cultures that are not killed by the current Lyme antibiotics, and there is interest to identify novel drug candidates that more effectively kill such forms. We previously evaluated 34 essential oils and identified some highly active candidates with excellent activity against biofilm and stationary phase B. burgdorferi. Here we screened another 35 essential oils and found 10 essential oils (garlic, allspice, cumin, palmarosa, myrrh, hedycheim, amyris, thyme white, litsea cubeba, lemon eucalyptus) and the active compoent of cinnamon bark cinnamaldehyde (CA) at a low concentration of 0.1% to have high activity against stationary phase B. burgdorferi. At a very low 0.05% concentration, garlic, allspice, palmarosa and CA still exhibited strong activity against the stationary phase B. burgdorferi. CA also showed strong activity against replicating B. burgdorferi, with a MIC of 0.02% (equivalent to 0.2 μg/mL). In subculture studies, the top 5 hits garlic, allspice, myrrh, hedycheim, and litsea cubeba completely eradicated all B. burgdorferi stationary phase cells at 0.1%, while palmarosa, lemon eucalyptus, amyris, cumin, and thyme white failed to do so as shown by visible spirochetal growth after 21-day subculture. At 0.05% concentration, only garlic essential oil and CA sterilized the B. burgdorferi stationary phase culture as shown by no regrowth during subculture,
while allspice, myrrh, hedycheim and litsea cubeba all had visible spirochetes growing during subculture. Future studies are needed to determine if these highly active essential oils could eradicate persistent B. burgdorferi infection in vivo."/www.biorxiv.org/content/early/2018/02/06/260091
This is a continuation of the previous essential oils study published by the same Johns Hopkins Bloomberg School of Public Health team lead by Ying Zhang. Older study about
oils available here: /www.frontiersin.org/articles/10.3389/fmed.2017.00169/full
The important finding in this study is IMHO garlic essential oil (cinnamon i think it was studied in the previous paper too). Apparently we should all eat more garlic than we do since it has a profound effect
on the borrelia bacteria in vitro, even against persisters. I am not sure if just eating garlic cloves can achieve the level of % needed of the essential oil but i assume one can buy essential garlic oil and supplement with that. We must wait for the final paper to be published for more details.
Zhang's team apparently will next be playing will these essential oils in vivo (mice?) and report us back the findings.