question about Pepsin

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

Regular Member

Date Joined Apr 2014
Total Posts : 205
   Posted 2/13/2018 2:07 PM (GMT -6)   
My new practitioner (an herbalist) put me on Pepsin (without HCL) in an effort to heal my gut. I recently recovered from an ulcer, gastritis, esophagitis and deudonitis (reluctantly took a PPI for this for several months), so I told her NO HCL.

After about 9 days on this Pepsin (without HCL), I started burping again and now have a near constant sore throat (symptoms of reflux for me....). Can Pepsin do this? If so, I may need to fire this woman!
Lyme, Bartonella, Rocky Mtn Spotted Fever, Mycoplasma, EBV, Coxsackie B, Chlamydia Pnemoniae, Parvo, Mold
Tried: Zhang (18 months), Cowden (3 months), LDI( 3months), UVLrx (3 months), now assortment of herbs, homeopathy, vitamins and detox.

Forum Moderator

Date Joined May 2014
Total Posts : 33957
   Posted 2/13/2018 2:45 PM (GMT -6)   
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

The Dude Abides
Veteran Member

Date Joined May 2017
Total Posts : 1157
   Posted 2/13/2018 3:22 PM (GMT -6)   
I'm not a Doctor, Pharmacist, or Healthcare Practitioner, but, in reading the following Abstract, it would seem that Pepsin might be contributing to your issue:

Reflux Revisited: Advancing the Role of Pepsin


Gastroesophageal reflux disease is mediated principally by acid. Today, we recognise reflux reaches beyond the esophagus, where pepsin, not acid, causes damage. Extraesophageal reflux occurs both as liquid and probably aerosol, the latter with a further reach. Pepsin is stable up to pH 7 and regains activity after reacidification. The enzyme adheres to laryngeal cells, depletes its defences, and causes further damage internally after its endocytosis. Extraesophageal reflux can today be detected by recognising pharyngeal acidification using a miniaturised pH probe and by the identification of pepsin in saliva and in exhaled breath condensate by a rapid, sensitive, and specific immunoassay. Proton pump inhibitors do not help the majority with extraesophageal reflux but specifically formulated alginates, which sieve pepsin, give benefit. These new insights may lead to the development of novel drugs that dramatically reduce pepsinogen secretion, block the effects of adherent pepsin, and give corresponding clinical benefit.


Also, one of the above authors, Peter Dettmar, is referenced in the following articles:

What Is Silent Reflux? The Mechanism Revealed!

Interview: Prof. Peter Dettmar – the Role of Pepsin in LPR

I hope this helps. Or, at least, leads you to something that helps.
New Topic Post Reply Printable Version
Forum Information
Currently it is Tuesday, August 21, 2018 7:28 AM (GMT -6)
There are a total of 2,995,038 posts in 328,189 threads.
View Active Threads

Who's Online
This forum has 161314 registered members. Please welcome our newest member, Smith Bella.
260 Guest(s), 5 Registered Member(s) are currently online.  Details
GreenBeans, physedgirl09, KitKat880, Markus3326, Going for brachy