Lipids and/or Lipid Peroxidation

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Georgia Hunter
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Date Joined May 2012
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   Posted 2/17/2018 2:15 AM (GMT -6)   
Many of us have issues with increased lipid peroxidation that can't be attributed to any one cause. We aren't drinkers, we don't eat too many fatty foods, but yet we still have issues. Perhaps our body is trying to "help us out" and kill some kind of pathogen. I don't think this pathogen applies to most of us, but interesting none the less.

/www.ncbi.nlm.nih.gov/pmc/articles/PMC105821/

The Dude Abides
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   Posted 2/17/2018 3:01 AM (GMT -6)   
Would "Lipid Replacement Therapy" help with lipid peroxidation?

/www.healingwell.com/community/default.aspx?f=30&m=3947503

Georgia Hunter
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Date Joined May 2012
Total Posts : 2116
   Posted 2/17/2018 4:29 AM (GMT -6)   
Yes it would. The reason we need it is because our infections cause too many free radicals and we just can't keep up with eliminating them. They bind the lipid membrane and damage it.

Psilociraptor
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Date Joined Jul 2016
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   Posted 2/17/2018 6:43 AM (GMT -6)   
This has been an interesting topic to me for a while. LDL and HDL shuttle fat soluble cell wall toxins like lipoteichoic acids and lipopolysaccharides back to the liver for excretion. VLDL, Lp(a), Cholesterol, and Lipase activity are all regulated by inflammatory mediators. It's pretty obvious cardiometabolic disorders are aberrations of the acute phase response. But I wish I knew the specific role, if any, of lipid peroxidation and cholesterol deposition. Maybe just to soluble-ize cell wall antigens? Repair damaged tissues? Kill pathogens? All the above?

On an anecdotal level my lipid panels were atrocious after getting Lyme. Granted I never checked them before, being young, but my Lp(a) was orders of magnitude higher than the reference range as was my myeloperoxidase, sdLDL, etc. Scary stuff

Georgia Hunter
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Date Joined May 2012
Total Posts : 2116
   Posted 2/17/2018 11:04 AM (GMT -6)   
Psilociraptor said...
This has been an interesting topic to me for a while. LDL and HDL shuttle fat soluble cell wall toxins like lipoteichoic acids and lipopolysaccharides back to the liver for excretion. VLDL, Lp(a), Cholesterol, and Lipase activity are all regulated by inflammatory mediators. It's pretty obvious cardiometabolic disorders are aberrations of the acute phase response. But I wish I knew the specific role, if any, of lipid peroxidation and cholesterol deposition. Maybe just to soluble-ize cell wall antigens? Repair damaged tissues? Kill pathogens? All the above?

On an anecdotal level my lipid panels were atrocious after getting Lyme. Granted I never checked them before, being young, but my Lp(a) was orders of magnitude higher than the reference range as was my myeloperoxidase, sdLDL, etc. Scary stuff


The reason I started this thread was for the exact reason you mentioned, killing pathogens. Our immune response is responsible not only killing pathogens but also for squelching free radicals. It takes charged molecules and bonds them with the charged element of the pathogen or the free radical. This makes something hydrophobic become hydrophilic and allows it to be eliminated. We have a limited supply of charged molecules to do this and when that supply runs out,our body utilizes the lipid membranes of the mitochondria or cell walls as a charged molecule. Like I've said, it's robbing Peter to pay Paul. This is why all of us here have too much lipid peroxidation. The LPS presence drains our resources through cytokine release.
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