Minocycline and plaquenil

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Regular Member

Date Joined Sep 2017
Total Posts : 146
   Posted 2/21/2018 2:22 PM (GMT -6)   
Hi guys, I have been taking minocycline for a few months now and have made good progress but I still suffer from joint pain and a few weird neuro and eye problems.

I went to see my Llmd the other day and he has said to add plaquenil. Has anyone any experience of this combo?

Is it a good combination to be on? And Should I expect to herx from adding this?.. the first 6 weeks on minocycline were hell but then the improvement was massive from where i was.

I have been back at work for 6 weeks all be it a struggle and im a little concerned about needing more time off.

Veteran Member

Date Joined Mar 2014
Total Posts : 1664
   Posted 2/21/2018 3:47 PM (GMT -6)   
I've taken both as pair with an anti-viral and/or anti-fungal, and occasionally with Rifampin.

Mino has benefits over Doxy with less sun and stomach issues, and good brain penetration. Plaq is said to be a mild cyst buster and improves cell alkaline levels to help some ABX penetrate better.

In my opinion it's a fairly mild and well tolerated combo, but I'm a pretty heavy blast 'em hard type person.

Work is always a struggle. I worked a four day work week for my first two or so years of treatment.
Went back full time while still on IV.

Regular Member

Date Joined Sep 2017
Total Posts : 146
   Posted 2/21/2018 4:12 PM (GMT -6)   
Thanks for the reply, did you get decent results from this combo?

Forum Moderator

Date Joined May 2014
Total Posts : 33895
   Posted 2/21/2018 5:04 PM (GMT -6)   
The one thing that concerns me about the Plaquenil is the half life is about 50 days. So, after even just a couple weeks on it...it would take you many months for it to leave your system.

Also, you should get a baseline eye test before or shortly after starting the Plaquenil.

And, then yearly exams after that to check for Retinopathy.
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

Veteran Member

Date Joined Mar 2014
Total Posts : 1664
   Posted 2/22/2018 8:11 AM (GMT -6)   
The last time I used both Mino and Plaq together in my protocol I was near the end of my treatment and thought I was having good results.

Hope this helps. Girlie made a good point about eye tests. I get an annual eye exam and my doctor is aware of my Lyme dx and plaquenil use.

Village Crazy Lady
Regular Member

Date Joined Feb 2017
Total Posts : 386
   Posted 2/24/2018 12:50 AM (GMT -6)   
Hey Spanish

I’ve been taking plaq for over a year now with all of the abx combos I’ve cycled thru including mino, only stopping it the weeks I’m pulsing Tinda.

I haven’t had any problems with it but i stick to a good detox program.

I do see my Retina Specialist regularly to ensure no added problems are happening.

Hang in

~~~Your Life is an Occasion, Rise to It ~~~

Symptoms for years and years, Diag 6/2016, LLMD 10/2016
Treating with Abx and company

Regular Member

Date Joined Sep 2017
Total Posts : 146
   Posted 2/24/2018 3:50 PM (GMT -6)   
Thanks for the replies, I have to say I am a bit worried about the possible side effects but I do trust my Llmd, hes been great so far so I guess Ill just get regular eye tests to make sure everything is ok.
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