Help! Need to take Rifampin but it lowers blood levels of my anti-depressant!

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Regular Member

Date Joined Feb 2018
Total Posts : 29
   Posted 2/25/2018 7:59 AM (GMT -6)   
has anyone been on Rifampin and also anti-depressants?
How did you manage when the Rifampin lowers the SSRI's effect
Did you up your dosage of anti -D

Veteran Member

Date Joined Sep 2016
Total Posts : 2112
   Posted 2/25/2018 1:40 PM (GMT -6)   
bumping for more views

Forum Moderator

Date Joined May 2014
Total Posts : 32611
   Posted 2/25/2018 6:41 PM (GMT -6)   
Zita - Have you checked out Rifabutin.

I put Rifampin and an SSRI in the Drug Interaction report and it showed "moderate" for lowering the effects.

I then put the same SSRI in the report with Rifabutin and it came up showing no interactions.

I haven't checked out any other interaction reports though.
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

Veteran Member

Date Joined Nov 2015
Total Posts : 4715
   Posted 2/26/2018 1:43 AM (GMT -6)   
add st jons and get vit d up with sun if your not on doxy...also mucuna is a source of dopamine since our gut dont make it any more ...

LymeSick 🌟
Regular Member

Date Joined Aug 2017
Total Posts : 234
   Posted 3/4/2018 2:24 PM (GMT -6)   
Hi, from what I've read we need to go up on our antidepressants, sometimes up to 3 times higher, while on Rifampin. But talk to your doctor first.
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