The half-life is 11-16 hours or 11-22 hours - I've seen both.
So, it's not a really short half-life.
I've not known anyone to take the 200 mg once daily.
If you take it 12 hours apart...you still have half of the previous dose in your blood most likely. (by the time you take the second dose)
I would stick to 100 twice daily unless a LLMD is telling you otherwise.
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi