Metabolic Pathways Chart - For Science Geeks

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The Dude Abides
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   Posted 2/28/2018 4:06 PM (GMT -6)   
This is something I found and thought that some of you science geeks might find interesting:

Metabolic Pathways Chart
bit.ly/2EYW1wT

All it did for me is hurt my eyes and give me a headache. It's way over my head.

LymeSick 🌟
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Date Joined Aug 2017
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   Posted 2/28/2018 6:16 PM (GMT -6)   
Hmm what happens after Adrenaline? The arrows just stop.

bluelyme
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   Posted 2/28/2018 9:28 PM (GMT -6)   
i thinks it does what it does then nor epinephrine cancels it ...georgia ..daises?

that poster is badasserery ...thanks dude so much

Psilociraptor
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   Posted 2/28/2018 10:37 PM (GMT -6)   
lol i almost bought this poster at one point. not sure how the wife would feel about it on the wall. but it is a pretty rad graphic

Georgia Hunter
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   Posted 3/1/2018 2:43 AM (GMT -6)   
bluelyme said...
i thinks it does what it does then nor epinephrine cancels it ...georgia ..daises?

that poster is badasserery ...thanks dude so much

It gets reabsorbed back into the neuron and broken down by COMT and MAO back into inactive metabolites.

Dude, that is one heck of a poster. I've studied a lot of that but never seen it all together. How can I get my hands on one of those?

One thing to remember about that poster, that is what is supposed to happen under optimal conditions. We don't have optimal conditions. Each of the reactions on that chart are pH and substrate dependent. There are also physical limitations we must overcome. It doesn't do you any good if your substrate that catalyzes a reaction isn't located where it is supposed to be. An example, if your cobalamin is outside the cell, it can't react with homocysteine to produce methionine inside the cell. It must be able to enter the cell.

I can see so many reactions that require magnesium or zinc for them to occur. So if I were trying to slow down or stop this cycle, I'd reduce the concentration of these substrates. But we have a lot more issues than just that. We have entire molecules that aren't there. Robbing Peter to pay Paul has its consequences.

astroman
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   Posted 3/1/2018 9:37 AM (GMT -6)   
This is one big mess when its all together. Not the best way to "vision" it!

Psilociraptor
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   Posted 3/1/2018 12:17 PM (GMT -6)   
astroman said...
This is one big mess when its all together. Not the best way to "vision" it!


Definitely not your first time learning it! But i do think it is a good way to easily go back and refresh what connects to what. I would like to see one of these for bacterial metabolism lol... Been brushing up my basic microbiology and good lord it makes this poster look like childs play. There are no freakin rules out there. What a crazy world we live in

astroman
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   Posted 3/1/2018 12:35 PM (GMT -6)   
I like the individual parts of this shown on heartfixer.com , they have good info on this too.

And just "goggle imaging" one pathway shows so many different ways to illustrate each one - can pick the one clearest to you.

Girlie
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   Posted 3/1/2018 1:56 PM (GMT -6)   
TMI
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

The Dude Abides
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Date Joined May 2017
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   Posted 3/1/2018 8:10 PM (GMT -6)   
Georgia Hunter said...
Dude, that is one heck of a poster. I've studied a lot of that but never seen it all together. How can I get my hands on one of those?


When I saw that chart, you were the first person that came to mind!

I finally found a link to purchase it, but they didn't make it easy.

/www.sigmaaldrich.com/life-science/metabolomics/learning-center/metabolic-pathways.html

From the above page, click the "Order Your Copy Today!" link.

The poster size is 33 in. × 50 in. and costs $13.30.

If they have other posters, I sure can't find them!

LymeSick 🌟
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Date Joined Aug 2017
Total Posts : 234
   Posted 3/1/2018 8:26 PM (GMT -6)   

bluelyme
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   Posted 3/2/2018 12:07 AM (GMT -6)   
now your talkin ...thanks lymsic

The Dude Abides
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Date Joined May 2017
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   Posted 3/2/2018 1:20 AM (GMT -6)   
Good grief! That's WAAAAAY more complicated than I imagined. I may have to scrap my plans to build a human from scratch.

Nice find, LymeSick 🌟!

Georgia Hunter
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Date Joined May 2012
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   Posted 3/2/2018 3:58 AM (GMT -6)   
Good find LymeSick and thanks Dude.

As an example, in LymeSick's chart, it shows 6 catalysts for one step in the breakdown of ATP. When we have Lyme, some of our catalysts aren't there so this chart doesn't function like it is supposed to. Alternate pathways come into effect. So in essence, our metabolism pathways or as some call it, our detox pathways, become less effective. Methylation is a detox pathway and takes a big hit. If your detox pathways don't reduce to the point where they can't eliminate and breakdown products, you won't get sick. This is why some get sick and some don't and why some get very sick.

WalkingbyFaith
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Date Joined Aug 2017
Total Posts : 1682
   Posted 3/2/2018 9:35 AM (GMT -6)   
Georgia Hunter said...
Good find LymeSick and thanks Dude.

As an example, in LymeSick's chart, it shows 6 catalysts for one step in the breakdown of ATP. When we have Lyme, some of our catalysts aren't there so this chart doesn't function like it is supposed to. Alternate pathways come into effect. So in essence, our metabolism pathways or as some call it, our detox pathways, become less effective. Methylation is a detox pathway and takes a big hit. If your detox pathways don't reduce to the point where they can't eliminate and breakdown products, you won't get sick. This is why some get sick and some don't and why some get very sick.


And I suppose there's no easy way to identify where and to what extent our pathways have stopped working and how to effectively fix them again, else we wouldn't all be here struggling and searching for answers.

astroman
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Date Joined Mar 2014
Total Posts : 4880
   Posted 3/2/2018 1:35 PM (GMT -6)   
WalkingbyFaith said...
Georgia Hunter said...
Good find LymeSick and thanks Dude.

As an example, in LymeSick's chart, it shows 6 catalysts for one step in the breakdown of ATP. When we have Lyme, some of our catalysts aren't there so this chart doesn't function like it is supposed to. Alternate pathways come into effect. So in essence, our metabolism pathways or as some call it, our detox pathways, become less effective. Methylation is a detox pathway and takes a big hit. If your detox pathways don't reduce to the point where they can't eliminate and breakdown products, you won't get sick. This is why some get sick and some don't and why some get very sick.


And I suppose there's no easy way to identify where and to what extent our pathways have stopped working and how to effectively fix them again, else we wouldn't all be here struggling and searching for answers.


Not easy, but as you know, our methalation changes with lyme is also about our individual genetic defects, many illness are.

Although it takes time, its not impossible to partially improve this. Looking at ones genes and reading / learning about solutions to these pathways can improve your health. Some people have done this to some extent. Not completely as its truly work in progress. Of course there are some you probably cant change..yet.

Amino acids and certain minerals individually are cheap, and these can make positive changes if one does the detective work.

Georgia Hunter
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Date Joined May 2012
Total Posts : 2116
   Posted 3/2/2018 4:40 PM (GMT -6)   
WalkingbyFaith said...
Georgia Hunter said...
Good find LymeSick and thanks Dude.

As an example, in LymeSick's chart, it shows 6 catalysts for one step in the breakdown of ATP. When we have Lyme, some of our catalysts aren't there so this chart doesn't function like it is supposed to. Alternate pathways come into effect. So in essence, our metabolism pathways or as some call it, our detox pathways, become less effective. Methylation is a detox pathway and takes a big hit. If your detox pathways don't reduce to the point where they can't eliminate and breakdown products, you won't get sick. This is why some get sick and some don't and why some get very sick.


And I suppose there's no easy way to identify where and to what extent our pathways have stopped working and how to effectively fix them again, else we wouldn't all be here struggling and searching for answers.

No way to know, but we can improve both physiological function and gene function. The key is reducing our pathogen load, correcting the GI bacteria, and increasing nutrients that are depleted.
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