Help with understand test results

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Cascades
New Member


Date Joined Nov 2017
Total Posts : 15
   Posted 3/7/2018 4:24 PM (GMT -6)   
My daughter just received her IGeneX test results, can anyone help shed some light on these. It appears she has a positive IgM and a negative IgG, not sure what that means, thanks for your help

ImmunoBlot igM , 23+, 31++, 39+, 41++, 93-

ImmunoBlot igG 18-, 23 IND, 28-, 30-, 35-, 41 IND, 45-, 58-. 66-, 93-

goshawk
Veteran Member


Date Joined Sep 2016
Total Posts : 2101
   Posted 3/7/2018 6:13 PM (GMT -6)   
Hi Cascades,

Here is some information and others that are more experience to explain will be along soon to help out.

Im sorry that your daughter has Lyme. Take care, Jo

23-25 outer surface protein C (OspC), specific for Bb(Lyme)
31 outer surface protein A (OspA), specific for Bb
39 Bacterial membrane protein A (BmpA); specific for Bb

Cascades
New Member


Date Joined Nov 2017
Total Posts : 15
   Posted 3/7/2018 6:19 PM (GMT -6)   
what we are confused about is that this would not be a recent exposure, it wasn't until I was diagnosed that she mentioned that all her joints hurt ( she is 39 ) and that she was having some memory issues, I ordered the IgeneX test for her, so we are puzzled by the negative IgG

Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 32503
   Posted 3/7/2018 6:22 PM (GMT -6)   
Cascades said...
My daughter just received her IGeneX test results, can anyone help shed some light on these. It appears she has a positive IgM and a negative IgG, not sure what that means, thanks for your help

ImmunoBlot igM , 23+, 31++, 39+, 41++, 93-

ImmunoBlot igG 18-, 23 IND, 28-, 30-, 35-, 41 IND, 45-, 58-. 66-, 93-


positive IgM and Negative IgG is often seen. (It was for both me and my husband, as well as others I've seen)

Is that also CDC positive with all those bands positive on the IgM?

Your daughter has lyme disease.
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

Post Edited (Girlie) : 3/7/2018 5:27:12 PM (GMT-7)


Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 32503
   Posted 3/7/2018 6:25 PM (GMT -6)   
Cascades said...
what we are confused about is that this would not be a recent exposure, it wasn't until I was diagnosed that she mentioned that all her joints hurt ( she is 39 ) and that she was having some memory issues, I ordered the IgeneX test for her, so we are puzzled by the negative IgG



With most diseases, the IgM antibodies switch over to IgG within a matter of weeks...or a couple months.
But with Lyme disease this usually doesn't happen. It can stay IgM positive for many months to years....possibly indicating an ongoing reactivation.

Dr.J says this on his website:
"In almost all infection models, after just a few weeks, the IgM antibody level wanes to the point of being non-detectable and does not recur.
However, a confounding fact in Bb infections is that the IgM antibody may persist for years, a very unusual situation in most disease states. "Logically, one would have to conclude that this reflects an ongoing reactivation or persisting and continually renewing infectious state of Bb infection. Most active diagnostic laboratories involved with LD tend to agree with this notion. "

jemsekspecialty.com/laboratory-testing-for-lyme-disease/
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

Cascades
New Member


Date Joined Nov 2017
Total Posts : 15
   Posted 3/7/2018 11:14 PM (GMT -6)   
thank you SO MUCH for responding
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