what we are confused about is that this would not be a recent exposure, it wasn't until I was diagnosed that she mentioned that all her joints hurt ( she is 39 ) and that she was having some memory issues, I ordered the IgeneX test for her, so we are puzzled by the negative IgG
With most diseases, the IgM antibodies switch over to IgG within a matter of weeks...or a couple months.
But with Lyme disease this usually doesn't happen. It can stay IgM positive for many months to years....possibly indicating an ongoing reactivation.
Dr.J says this on his website:
"In almost all infection models, after just a few weeks, the IgM antibody level wanes to the point of being non-detectable and does not recur.
However, a confounding fact in Bb infections is that the IgM antibody may persist for years, a very unusual situation in most disease states. "Logically, one would have to conclude that this reflects an ongoing reactivation or persisting and continually renewing infectious state of Bb infection. Most active diagnostic laboratories involved with LD tend to agree with this notion. "jemsekspecialty.com/laboratory-testing-for-lyme-disease/
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi