Low T-cell response in mice with Lyme, Pub Med

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Date Joined Mar 2014
Total Posts : 5095
   Posted 3/20/2018 1:19 PM (GMT -6)   
"T-Cell-Independent Responses to Borrelia burgdorferi Are Critical for Protective Immunity and Resolution of Lyme Disease"


This is interesting. Mice with lyme bacteria and low T-cell response have arthritis.

".......Immunocompetent mice develop a consistent pattern of events following infection with B. burgdorferi. Within several days, local invasion and spirochetemia result in the evolution of arthritis and carditis, which peak within 2 to 3 weeks and then undergo immune-mediated resolution with bouts of recurrence over the course of 1 or more years of persistent infection (1, 7, 10).

Infection of severe combined immune deficient (SCID) mice results in persistent active carditis and progressively destructive arthritis........."

Goggling this, I see there are a few universitys (John Hopkins is one) researching T-cells and lyme and genes, which is great.

I made a post about genes that express/effect T-cells last month, 23andme can identify some of this.

Post Edited (astroman) : 3/20/2018 2:02:40 PM (GMT-6)

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