I started slow adding a drop a day. After a couple of weeks I started adding an evening dose, and then a week later I was able to increase more quickly. Pay attention to how you are feeling and backup the dose if you herx.
I started with nutramedix but switched to woodland essence. I used it for about 6 months for bart.
MTHTR single mutation; Positive Igenix IgG Jan 2017; March/Apr '17: doxy, Tinizadole. 5/1 samento and mino/tini. 5/28- back to doxy, added activated charcoal. 6/9 - stopped antibiox; staying with samento, red root and houttiya and supps. tried LDN; 8/24 rifampin, samento, red root and supps. On and off rifampin. 1/1/18 - 1/20 rifampin. Herbs and vitamins only now.