I'm right there with you and do not have any obvious advice.
As for your specific questions:
1) For me it has been an up down thing. Before I started treatment and during the first few months of treatment, I was almost constantly in a depersonalized state. As treatment went on, I would experience brief moments where I was almost rediscovering myself. Like "hey good friend, there you are...where have you been?" These moments became more frequent and for longer durations. Now I am more often "myself" than not, but I still get those moments where I think, "oh no, who am I and where did I go now?" These moments have become more laughable for me now, but I do still get them, and occasionally they are the cause for a brief, but intense panic attack...but I recover from the panic almost instantly now. Progress.
2) The prognosis for anyone with Lyme and coinfections is so personal and individual. Though I only had the anxiety and depersonalization for less than a handful of months before diagnosis and treatment, I've come to discover that I had many less severe symptoms of Lyme and coinfections for over 10 years. I always brushed these symptoms off as normal bodily inconveniences, just toughing it out. This delay in treatment of the minor symptoms has made it so I am now a chronic case, most likely treating for life. I do however believe that anyone healing anything needs to have a confident and clear mind to achieve full healing. I'm guessing your doctor is giving you a confidence boost by saying your prognosis is good. Hold on to that confidence boost and keep at it. You will improve one way or another as long as you keep trying.
DX Borrelia, Babesia, Bartonella and Ehrlichia June 2017.
Symptoms since at least 2007.
Started treatment June 2017
-Artemisinin, A BART, A BAB, Biaxin, Chlorella, Liposomal Glutathione, Magnesium, Omnicef, Prothrivers Wellbrain, Tindazole, Tranquility, Uplift, Fish Oil, B Vitamins, Vitamin D, gluten free, sugar free, dairy free, lemon water, detox tea, coffee enemas.