Is true that rocephin don't cross the Bibb?

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OriolCarol
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Date Joined Dec 2017
Total Posts : 559
   Posted 3/22/2018 3:40 PM (GMT -6)   
Is true that rocephin don't cross the Bibb?

https://www.ncbi.nlm.nih.gov/m/pubmed/2582913/ mad

OriolCarol
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Date Joined Dec 2017
Total Posts : 559
   Posted 3/22/2018 3:41 PM (GMT -6)   
Sarah vaughter (i don't think she is right) says that if you take ceftriaxone, you're wasting your time.

She say that the only antibiotics that cross Bibb are mino and doxy.

Hoagie
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Date Joined Jul 2017
Total Posts : 615
   Posted 3/22/2018 4:00 PM (GMT -6)   
I don't have the data in front of me, but I'm quite sure Rocephin crosses the BBB. I have read studies of rocephin alone being used for brain infections. Also, there are quite of few oral abx that penetrate the BBB.

Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 32635
   Posted 3/22/2018 4:50 PM (GMT -6)   
I wouldn't worry about it because it is a known IV antibiotic for lyme..so it should do the job.

It seems that there's conflicting info on which ones do pass the b/b barrier.

LymeMD says Penicillin does...but I was told it doesn't.
He also says Cephalosporins "do not do as good a job'

He states doxy and mino do, but macrolides don't much.

Flagyl and Tinidazole do a good job.

Here's what he wrote about IV Rocephin:

I haven't talked about Rocephin, our favorite intravenous Lyme drug. It is a cephalosporin. Above I state above this class of drugs generally has poor penetration into the brain. Apparently some cephalosporins penetrate better than others. Literature about Rocephin is mixed; but contrary to many claims, it does pass the blood brain barrier. Let me mention that Rocephin is used a lot for meningitis. In typical meningitis with active inflammation, there is a breakdown of the BBB and most antibiotics penetrate. With typical chronic Lyme, neuroborreliosis patients, there is no active inflammation. High doses of the drug, with high serum levels obviates the BBB problem. Rocephin is generally tolerated at high doses. Rocephin has other favorable properties: the long half life with once daily dosing, makes it easy to use this effective intravenous therapy at home. Even though some oral medications have better penetration through the BBB: the IV route makes Rocephin work better.

lymemd.blogspot.ca/2013/03/blood-brain-barrier.html
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

Post Edited (Girlie) : 3/22/2018 4:56:59 PM (GMT-6)


bluelyme
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Date Joined Nov 2015
Total Posts : 4715
   Posted 3/23/2018 2:29 AM (GMT -6)   
roceph does have anti-inflammitory properties...a year + pulsing did me good with bvt

OriolCarol
Veteran Member


Date Joined Dec 2017
Total Posts : 559
   Posted 3/23/2018 6:07 AM (GMT -6)   
High doses of the drug, with high serum levels obviates the BBB problem. Rocephin is generally tolerated at high doses

When he say high doses of rocephin it could be 4gr right?

OriolCarol
Veteran Member


Date Joined Dec 2017
Total Posts : 559
   Posted 3/23/2018 5:39 PM (GMT -6)   
The chinese study says that it doesn't cross Bibb, but if it was true how is possible that some als patients have recovered.... or Dr. Martz for example... without active meningitis so the bbb is not permeable...

Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 32635
   Posted 3/23/2018 5:45 PM (GMT -6)   
I wouldn’t question the rocephin - re: effectiveness (if I were you) - as it is commonly used for Lyme treatment.
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi
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