Rifampin Along with Diflucan and Nystatin - Liver??

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NicHostetler
Veteran Member


Date Joined Mar 2017
Total Posts : 622
   Posted 3/28/2018 8:33 AM (GMT -6)   
I had a conversation with my doctor about the possibility of yeast issues and she wants me to take Rifampin and Zithromax along with Nystatin twice a day and diflucan twice a week.

I'm pretty sure that you aren't supposed to take milk thistle with rifampian and I know all these things are pretty rough on your liver.

I have had elevated liver enzymes (slight) every time I get my blood tests done, so this is very concerning to me.

Has anyone else taken all these things? Or have any comments?

I already feel like crap due to die off from the lauricidin and nystatin, I cant imagine dealing with bart herx's too. But, if it gets me better I'm up for anything, just not permanent damage.

astroman
Veteran Member


Date Joined Mar 2014
Total Posts : 4880
   Posted 3/28/2018 10:10 AM (GMT -6)   
"I have had elevated liver enzymes (slight) every time I get my blood tests done, so this is very concerning to me."

- thats not all that uncommon, they bounce back down when your off "killer meds".

Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 32656
   Posted 3/28/2018 10:33 AM (GMT -6)   
So, your liver function tests aren't climbing...they are staying slightly elevated?

If that's the case...should be okay.

I think as long as you keep testing after you've added in the Diflucan twice weekly...that would catch any effect that the Diflucan is having.

Keep an eye on it.
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

NicHostetler
Veteran Member


Date Joined Mar 2017
Total Posts : 622
   Posted 3/28/2018 11:01 AM (GMT -6)   
Well, let me restate that, without the Milk Thistle my liver enzymes were pretty high. With the Milk Thistle they stayed just slightly elevated.

From what I have read, Milk Thistle cant be taken with Rifampin.

I guess I could rely on Dandelion tea..?
Very sick starting around 07/2016
Started treatment 03/2017
Bixain & Cefdinir - 3 months - plateaued
Then Biaxin & Minocycline - 3 months - did not improve
Tinidazole - 500MG 2x a day - 2 weeks
Now taking:
Mepron 5mL 2x a day
Zithromax
Nystatin
Cats Claw - 30 drops 2x a day
Gou Teng - 30 drops 2x a day
CSA - 40 drops 2x a day
Japanese Knotweed - 40 drops 2x a day

Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 32656
   Posted 3/28/2018 11:06 AM (GMT -6)   
NicHostetler said...
Well, let me restate that, without the Milk Thistle my liver enzymes were pretty high. With the Milk Thistle they stayed just slightly elevated.

From what I have read, Milk Thistle cant be taken with Rifampin.

I guess I could rely on Dandelion tea..?


I switched from Milk Thistle to Pekana apo-hepat when my liver enzymes climbed at one point.
So far, so good.

It's homeopathic...and I took it with Rifampin per my LLND.

Maybe ask your LLMD about it?

FYI - I put MT in the drug interaction checker I use with Rifampin and it didn't show an interaction.


/www.drugs.com/interactions-check.php?drug_list=1633-0,2012-0

I wonder why.


My Interactions List: (Unsaved) Email Print Save Start Over
milk thistle
rifampin

Interactions between your drugs
No results found in our database - however, this does not necessarily mean no interactions exist. Always consult with your doctor or pharmacist.
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

astroman
Veteran Member


Date Joined Mar 2014
Total Posts : 4880
   Posted 3/28/2018 11:11 AM (GMT -6)   
"aren't supposed to take milk thistle with rifampian"

- thats interesting.

Alpha lipoic acid (ALA) is great for liver health and detox.

D-limonene too, just separate from meds a few hours if you can.

NicHostetler
Veteran Member


Date Joined Mar 2017
Total Posts : 622
   Posted 3/28/2018 11:42 AM (GMT -6)   
ok so maybe I'm wrong.. that makes me feel better! And Girlie, I tried to find it online but it looks like you have to get it through a doctor. I'll ask her about it.
Very sick starting around 07/2016
Started treatment 03/2017
Bixain & Cefdinir - 3 months - plateaued
Then Biaxin & Minocycline - 3 months - did not improve
Tinidazole - 500MG 2x a day - 2 weeks
Now taking:
Mepron 5mL 2x a day
Zithromax
Nystatin
Cats Claw - 30 drops 2x a day
Gou Teng - 30 drops 2x a day
CSA - 40 drops 2x a day
Japanese Knotweed - 40 drops 2x a day

Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 32656
   Posted 3/28/2018 12:05 PM (GMT -6)   
This site says you can contact them to get the password.

www.forresthealth.com/apo-hepat-homeopathic-liver-support-drops.html


And at a glance - you may be able to order through this site:

/well.ca/products/pekanaapo-hepat_142742.html
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

insomniaaa
Regular Member


Date Joined Apr 2017
Total Posts : 150
   Posted 3/28/2018 5:09 PM (GMT -6)   
My LLMD told me to take the milk thistle seed extract (silymarin) while being on Rifampin.

It probably slightly decreases the Rifampin's effectiveness but I'm willing to accept that tradeoff for the added hepatoprotective benefit.

Silymarin protects liver against toxic effects of anti-tuberculosis drugs in experimental animals
/www.ncbi.nlm.nih.gov/pmc/articles/PMC2491620/
A double-blinded randomized controlled trial of silymarin for the prevention of antituberculosis drug-induced liver injury
/www.ncbi.nlm.nih.gov/pmc/articles/PMC4580123/

Post Edited (insomniaaa) : 3/28/2018 5:17:41 PM (GMT-6)


NicHostetler
Veteran Member


Date Joined Mar 2017
Total Posts : 622
   Posted 3/29/2018 1:17 PM (GMT -6)   
Thank you so much everyone!! You guys are the best!!
Very sick starting around 07/2016
Started treatment 03/2017
Bixain & Cefdinir - 3 months - plateaued
Then Biaxin & Minocycline - 3 months - did not improve
Tinidazole - 500MG 2x a day - 2 weeks
Now taking:
Mepron 5mL 2x a day
Zithromax
Nystatin
Cats Claw - 30 drops 2x a day
Gou Teng - 30 drops 2x a day
CSA - 40 drops 2x a day
Japanese Knotweed - 40 drops 2x a day
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