Gosh yes! Our DS herxed so badly on it when he started with the LLMD/NP they pulled him off it and put him on pulsed minocycline plus other stuff for his co-infections. Detoxing is key and you could try hot foot baths with magnesium to see if it gives some relief.
Parent of teen DS w/ CDC+ Lyme test Nov 2015, late stage Lyme + mycoplasma, bartonella, babesia. Currently treating with antibiotics/anti-malerials, multivitamin, magnesium, Charlotte's Web Advanced CBD oil.
Website I started: ParentsofLymeKids.com
aka Lyme Disease 101 for Parents