I think the problem is more related to antibiotic doses, than to the combinations ... There is no study done in ALS patients with 4g of ceftriaxone and tinidazole or doses above 600mg with doxycycline, or 400 mg of minocycline ( as soon as the patients deteriorated with mino, the dose was reduced or the treatment stopped)
No OriolCarol, it's the combination. Take a look at this table, ceftriaxone leaves 68% of persister form borrelia alive:journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0117207.t002
C is control (water) , so ceftriaxone + C means only ceftriaxone
Notice Doxy with C leaves 72% alive !!!
Doxy with rifampin leaves 60% alive. so a bit better.
However take a look at Doxy+CefP+Dap (Doxy + Cefoperazone + Daptomycin) = it leaves only 19% alive!! That is WAY BETTER than anything on that table.
This type of research has first been done in 2015, most mainstream doctors are clueless about
borrelia being able to survive one antibiotic let alone 3, It's because everybody tested the early borrelia infection which has no persister bacteria and when Doxy achieves 92%+ kill rate and the rest of the bacteria is quickly removed by the immune system.
Take a look at this tablejournals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0117207.t001
In the first 3 days of infection, doxy is almost totally deadly to borrelia killing more than 92% of all bacteria.
7 days later, some of the borrelia bacteria has already created "strongholds" meaning they switched to persister round form, and then u see doxy leaves 71% alive !
10 more days and u have doxy leaving 80% alive, basically it gets closer to no activity at all. It is a miracle some people still recover with doxy, months after being infected... It's such a bad treatment for lyme persistent form ... Probably the people with very strong immune systems are helped a bit by antibiotic and manage to conquer the infection on their own. But if u stay years with this borrelia in your blood, it's game over for doxy to help you win.
So this type of study shows it all, in clear light, for everyone that has eyes and knows basic arithmetic to see. There is no point in asking around or see what other members of the forum think. You can make your own judgement by just looking at these tables. It's not rocket science.