Macrolide Roxithromycine help

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Regular Member

Date Joined Mar 2018
Total Posts : 110
   Posted 4/17/2018 12:02 PM (GMT -6)   
Hello again,

Started yesterday taking Roxithromycine 300mg after dinner. Had a very hard time to sleep and had a nightmare. When almost falling asleep i got jolt awake. This didnt stop for 2 hours. Is this a herx or SIDE effect? Anyone had similar experience?

I also started tinidazol, i hope ir doesnt affect sleep also.
Can anyone give feedback,please?


Veteran Member

Date Joined Feb 2016
Total Posts : 536
   Posted 4/17/2018 2:25 PM (GMT -6)   
I have this. Had it nearly every night for 5 years. As soon as i start to cross the barrier into sleep, my body goes into this panic and does everything it can to wake me up. It's instant, like i got struck with a lightening bolt.

After several doctors telling me i needed a psychiatrist, finally one told me this is dysautonomia. That's fairly common with us so a symptom of die-off from a new antibiotic sounds reasonable to me. Little more brain inflammation

Hopefully an increase in detoxing will help but as scary as it is, it's normal i guess. For me actually, the only thing that helps once that starts is keeping myself awake for a bit and it fades away. Sorry you're experiencing this

Forum Moderator

Date Joined May 2014
Total Posts : 33790
   Posted 4/17/2018 2:36 PM (GMT -6)   
I had that jolting when trying to fall asleep early in my symptoms.

It was horrible. I then started to take Valerian before going to bed...I did that for a few months...and then it was fine after.
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

Regular Member

Date Joined Mar 2018
Total Posts : 110
   Posted 4/17/2018 3:03 PM (GMT -6)   
Thank you very much for all your feedback.
What about insomnia? Could it be herx?

Does burburpinella help this?

Regular Member

Date Joined Mar 2018
Total Posts : 110
   Posted 4/17/2018 3:28 PM (GMT -6)   
A strange symptom i have os i feel my Hair startling or something moving around my Hair. Did any of you get this or heard about it?
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