Cost-effectiveness of longer-term versus shorter-term provision of antibiotics in patients with persistent symptoms attributed to Lyme disease
Published: April 2, 2018
Authors: Anneleen Berende , Lisette Nieuwenhuis, Hadewych J. M. ter Hofstede, Fidel J. Vos, Michiel L. Vogelaar, Mirjam Tromp, Henriët van Middendorp, A. Rogier T. Donders, Andrea W. M. Evers, Bart Jan Kullberg, Eddy M. M. Adang (all authors are from the Netherlands)/doi.org/10.1371/journal.pone.0195260
So the idea is they took some lyme patients, treat them all with 2 weeks of ceftriaxone (rocephin)
Next they split the treated ceftriaxone patients in 3 groups
- group 1 received 12 more weeks of doxy
- group 2 received 12 more weeks of clarithromycin + hydroxychloroquine. This is not considered "treatment with two antibiotics", plaquenil (hydroxychloroquine) here just augments the effects of clarithromycin in low pH environments (inside cells).
- group 3 received placebo
The longer-term treatments were similar with regard to costs, effectiveness and cost-effectiveness compared to shorter-term treatment in patients with borreliosis-attributed persistent symptoms after one year of follow-up. Given the results of this study, and taking into account the external costs associated with antibiotic resistance, the shorter-term treatment is the antibiotic regimen of first choice."
I think this study (it is a fork of the larger "PLEASE" study done in the Netherlands) is good because it shows taking one antibiotic at a time is really bad idea and you can very well just do nothing and save the money (although even so there is no really big change in terms of $$).
You either do combination therapy (3-4 antibiotics AT THE SAME TIME) for which we know clinically from people on this forum and LLMDs there is improvement but there are no double blind placebo trials at all, or you just don't take anything and try to eat healthy, drink plenty of fresh water exercise (if u can) etc.... Maybe take some pain and sleep meds.
So DO NOT treat with mono-therapy (one single antibiotic) for months, it DOES NOT WORK.
PS: I wonder when will the medical community do really useful lyme placebo controlled trials!? Since tens of thousands of us patients are treated by LLMDs with more than one antibiotic, what is the usefulness of such study, testing just one antibiotic on people for 12 weeks !?
Is there anyone reading this post that gets long term treatment with just one antibiotic ? If so then please find a better LLMD, you will not get well like this...