Anyone good at math?

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Girlie
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Date Joined May 2014
Total Posts : 33957
   Posted 5/2/2018 4:38 PM (GMT -6)   
I'm on 2 weeks off now (abx)

I'm wondering at one point I will be at my baseline i.e.: all the Mepron is almost out of my system?

The prior two weeks, I did M/W/F 4 tsp/day and then last week I did Mon thru Fri 4 tsp/day.


The prior cycle I was M/W/F 2 weeks on and one week off.


I'm thinking it will take more than 2 weeks?

I really want to assess my baseline. I was feeling better just prior to starting this protocol. - for a couple of weeks.
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

caramba
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Date Joined Aug 2016
Total Posts : 605
   Posted 5/2/2018 5:07 PM (GMT -6)   
the half life is 2-3 days it seems. the plasma levels don't double if you double the dose, so I don't think it matters if you were pulsing or constant dose, the elimination likely driven from when you took it last.

96 hours and it should gone/inactive.

Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 33957
   Posted 5/2/2018 5:14 PM (GMT -6)   
caramba said...
the half life is 2-3 days it seems. the plasma levels don't double if you double the dose, so I don't think it matters if you were pulsing or constant dose, the elimination likely driven from when you took it last.

96 hours and it should gone/inactive.


Really? I didn’t know that. We had a member who was on Plaquenil - with a half life of 30-50 days and stopped taking it because she had side effects - was told it would take several months to be out of her system.
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 33957
   Posted 5/2/2018 6:07 PM (GMT -6)   
So 4 days after my last dose it’s out

Last dose was Friday - so it’s already gone -

Okeydokey -
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

Lapis_29
Veteran Member


Date Joined Sep 2017
Total Posts : 882
   Posted 5/2/2018 7:54 PM (GMT -6)   
lets say half life is 70 hours



After 18 days (70 x 6) there will be less than 1% of the drug remaining which is basically gone

Lapis_29
Veteran Member


Date Joined Sep 2017
Total Posts : 882
   Posted 5/2/2018 7:58 PM (GMT -6)   
Girlie said...
So 4 days after my last dose it’s out

Last dose was Friday - so it’s already gone -

Okeydokey -


no

after 70 hours 50% of the drug remains in your system. thats what half life means

after 140 hours 25% remains

after 210 hours 12.5% remains

etc

Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 33957
   Posted 5/2/2018 8:48 PM (GMT -6)   
Lapis_29 said...
Girlie said...
So 4 days after my last dose it’s out

Last dose was Friday - so it’s already gone -

Okeydokey -


no

after 70 hours 50% of the drug remains in your system. thats what half life means

after 140 hours 25% remains

after 210 hours 12.5% remains

etc


That's what I had thought...every 70 hours it's 50% of the previous amount - so 50% of the 25% or 12.5%...etc.it would take awhile...but caramba doesn't agree, so I thought maybe I was calculating it incorrectly.

So, here I am 5 days (120 hours?) later since my last dose (Friday night) - and I still have 25% left of that last dose...plus less leftover from the Friday morning dose...right?


So, not at baseline yet then. I'm hoping that's why I still feel sh-tty.
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

Post Edited (Girlie) : 5/2/2018 7:52:21 PM (GMT-6)


bluelyme
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Date Joined Nov 2015
Total Posts : 4915
   Posted 5/3/2018 5:14 AM (GMT -6)   
just 2 play advocate...not about half life ...but u do know the mechanism by which mepron works depleting enzymes for cell reproduction ...just curious if all abx over long term effect mitochondrial and dna ? in which case 3yrs of bombardment may take longer than 5 days to reach par........................fore

btw my stepdad needed loads of liquid ubiqunol to pull out spiral

Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 33957
   Posted 5/3/2018 10:53 AM (GMT -6)   
Blue - I think Mepron depletes coq10 - but apparently you’re not supposed to supplement it.



What do you mean: “...... to pull out spiral”
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

Post Edited (Girlie) : 5/4/2018 12:37:05 AM (GMT-6)


bluelyme
Veteran Member


Date Joined Nov 2015
Total Posts : 4915
   Posted 5/4/2018 1:19 AM (GMT -6)   
severe lethargy and depression spiral ....ya know the usual ,take some see how ya feel

Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 33957
   Posted 5/4/2018 1:38 AM (GMT -6)   
bluelyme said...
severe lethargy and depression spiral ....ya know the usual ,take some see how ya feel


I’m lucky - I don’t have fatigue/lethargy or depression.

Lol - “I’m lucky”. Sure I am rolleyes
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 33957
   Posted 5/4/2018 1:42 AM (GMT -6)   
Decent day today - minimal symptoms for most of the day.

We’ll see what tomorrow brings: 2 for 2 ?
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi
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