Anyone good at math?

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 32691
   Posted 5/2/2018 3:38 PM (GMT -6)   
I'm on 2 weeks off now (abx)

I'm wondering at one point I will be at my baseline i.e.: all the Mepron is almost out of my system?

The prior two weeks, I did M/W/F 4 tsp/day and then last week I did Mon thru Fri 4 tsp/day.


The prior cycle I was M/W/F 2 weeks on and one week off.


I'm thinking it will take more than 2 weeks?

I really want to assess my baseline. I was feeling better just prior to starting this protocol. - for a couple of weeks.
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

caramba
Veteran Member


Date Joined Aug 2016
Total Posts : 605
   Posted 5/2/2018 4:07 PM (GMT -6)   
the half life is 2-3 days it seems. the plasma levels don't double if you double the dose, so I don't think it matters if you were pulsing or constant dose, the elimination likely driven from when you took it last.

96 hours and it should gone/inactive.

Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 32691
   Posted 5/2/2018 4:14 PM (GMT -6)   
caramba said...
the half life is 2-3 days it seems. the plasma levels don't double if you double the dose, so I don't think it matters if you were pulsing or constant dose, the elimination likely driven from when you took it last.

96 hours and it should gone/inactive.


Really? I didn’t know that. We had a member who was on Plaquenil - with a half life of 30-50 days and stopped taking it because she had side effects - was told it would take several months to be out of her system.
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 32691
   Posted 5/2/2018 5:07 PM (GMT -6)   
So 4 days after my last dose it’s out

Last dose was Friday - so it’s already gone -

Okeydokey -
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

Lapis_29
Veteran Member


Date Joined Sep 2017
Total Posts : 845
   Posted 5/2/2018 6:54 PM (GMT -6)   
lets say half life is 70 hours



After 18 days (70 x 6) there will be less than 1% of the drug remaining which is basically gone

Lapis_29
Veteran Member


Date Joined Sep 2017
Total Posts : 845
   Posted 5/2/2018 6:58 PM (GMT -6)   
Girlie said...
So 4 days after my last dose it’s out

Last dose was Friday - so it’s already gone -

Okeydokey -


no

after 70 hours 50% of the drug remains in your system. thats what half life means

after 140 hours 25% remains

after 210 hours 12.5% remains

etc

Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 32691
   Posted 5/2/2018 7:48 PM (GMT -6)   
Lapis_29 said...
Girlie said...
So 4 days after my last dose it’s out

Last dose was Friday - so it’s already gone -

Okeydokey -


no

after 70 hours 50% of the drug remains in your system. thats what half life means

after 140 hours 25% remains

after 210 hours 12.5% remains

etc


That's what I had thought...every 70 hours it's 50% of the previous amount - so 50% of the 25% or 12.5%...etc.it would take awhile...but caramba doesn't agree, so I thought maybe I was calculating it incorrectly.

So, here I am 5 days (120 hours?) later since my last dose (Friday night) - and I still have 25% left of that last dose...plus less leftover from the Friday morning dose...right?


So, not at baseline yet then. I'm hoping that's why I still feel sh-tty.
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

Post Edited (Girlie) : 5/2/2018 7:52:21 PM (GMT-6)


bluelyme
Veteran Member


Date Joined Nov 2015
Total Posts : 4724
   Posted 5/3/2018 4:14 AM (GMT -6)   
just 2 play advocate...not about half life ...but u do know the mechanism by which mepron works depleting enzymes for cell reproduction ...just curious if all abx over long term effect mitochondrial and dna ? in which case 3yrs of bombardment may take longer than 5 days to reach par........................fore

btw my stepdad needed loads of liquid ubiqunol to pull out spiral

Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 32691
   Posted 5/3/2018 9:53 AM (GMT -6)   
Blue - I think Mepron depletes coq10 - but apparently you’re not supposed to supplement it.



What do you mean: “...... to pull out spiral”
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

Post Edited (Girlie) : 5/4/2018 12:37:05 AM (GMT-6)


bluelyme
Veteran Member


Date Joined Nov 2015
Total Posts : 4724
   Posted 5/4/2018 12:19 AM (GMT -6)   
severe lethargy and depression spiral ....ya know the usual ,take some see how ya feel

Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 32691
   Posted 5/4/2018 12:38 AM (GMT -6)   
bluelyme said...
severe lethargy and depression spiral ....ya know the usual ,take some see how ya feel


I’m lucky - I don’t have fatigue/lethargy or depression.

Lol - “I’m lucky”. Sure I am rolleyes
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 32691
   Posted 5/4/2018 12:42 AM (GMT -6)   
Decent day today - minimal symptoms for most of the day.

We’ll see what tomorrow brings: 2 for 2 ?
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi
New Topic Post Reply Printable Version
Forum Information
Currently it is Monday, June 25, 2018 10:01 AM (GMT -6)
There are a total of 2,975,008 posts in 326,234 threads.
View Active Threads


Who's Online
This forum has 161321 registered members. Please welcome our newest member, lowo1.
377 Guest(s), 12 Registered Member(s) are currently online.  Details
Vaajurooby, Jack@, Flying gal, notsosicklygirl, GoBucks, TAD4207, tickbite666, Spanish, Sherrine, Progressing, dbwilco, Hoosierhousewife