Rifampin and benzos lorazepam or oxazepam

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isitlyme
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Date Joined Mar 2018
Total Posts : 91
   Posted 5/15/2018 3:22 PM (GMT -6)   
Hello,

Can anyone help me on this, i read in wiki that rifampin can interfere with benzos like lorazepam and perhaps oxazepam wish os what i am taking. Does this mean its 24 hours interaction? Or can i separate the meds 2 hours between with no interferênce ? Any case like mine?

Missouri
Regular Member


Date Joined Sep 2017
Total Posts : 335
   Posted 5/15/2018 3:29 PM (GMT -6)   
I think what happens with Rifampin is it makes your body produce tons and tons of enzyme Cp450. High levels of that enzyme greatly reduce effectiveness of many drugs. Some drugs it increases effectiveness.

You should look into more and be careful. Once that enzyme level goes up, it takes about 7-10 days for the interaction effect to wear off.

isitlyme
Regular Member


Date Joined Mar 2018
Total Posts : 91
   Posted 5/15/2018 4:12 PM (GMT -6)   
I could use tetracycline, but have severe gastritis already, and tetracycline are acid in it self as i heard. In fact i tried doxyciclin and my stomach was burned for One entire week, only One pill. I had a rx for tetracycline generic form but i didnt even tried. Because ir seems natural SIDE effect from all tetracyclines are stomach pain irritatuon? I dont know if iv tetracycline has the same reaction. I could try it, perhaps someone got away from burning the stomach by taking IV?

Missouri
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Date Joined Sep 2017
Total Posts : 335
   Posted 5/16/2018 7:33 AM (GMT -6)   
I had a couple courses of Minocycline and one course of Doxycycline. I didn't get burning stomach during any of those treatments. FWIW - if the benzo you take is on the Rifampin interaction list, i wouldn't touch Rifampin with a 10 foot pole.

I'm not sure what antimicrobials are best when one has gastritis, but I can say Minocycline, Ceftin, Biaxin, and Clindamycin were very effective at making my symptoms go away.

You might start a new post asking for recommendations for treatment for one who has gastritis.

Girlie
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Date Joined May 2014
Total Posts : 32558
   Posted 5/16/2018 12:07 PM (GMT -6)   
isitlyme said...
Hello,

Can anyone help me on this, i read in wiki that rifampin can interfere with benzos like lorazepam and perhaps oxazepam wish os what i am taking. Does this mean its 24 hours interaction? Or can i separate the meds 2 hours between with no interferênce ? Any case like mine?


I believe it would depend on the half-life of the medication...

I think Rifampin is fairly short half-life...but if you're taking it twice daily, that could be an issue if you're trying to take the benzos.
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

Girlie
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Date Joined May 2014
Total Posts : 32558
   Posted 5/16/2018 12:11 PM (GMT -6)   
Interestingly when I plug lorazepam with Rifampin into the drug interaction checker - it says no interactions.
This checker usually does pick up on the p450 interactions...


My Interactions List: (Unsaved) Email Print Save Start Over
lorazepam
rifampin
Add / Remove drugs
ConsumerProfessional
Major (0) Moderate (0) Minor (0) Food (1) Therapeutic Duplication (0)
Interactions between your drugs
No results found in our database - however, this does not necessarily mean no interactions exist. Always consult with your doctor or pharmacist.


But lorazepam was listed on another site that showed interactions with p450 meds. I can't seem to paste the link to the site here.

the half-life of rifampin taken 300 mg dose is 3-4 hours

Are you taking the benzos once a day? Maybe if Rifampin is taken in the morning...even if there is a drug interaction...it would be reduced substantially by the evening. (12 hours apart)


A 600 mg dose of Rifampin has a half life of 5 hours - so if you do a once daily dosing - then that may be the better option. Take Riffy in the morning, benzo in the evening?
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

Post Edited (Girlie) : 5/16/2018 12:21:32 PM (GMT-6)


isitlyme
Regular Member


Date Joined Mar 2018
Total Posts : 91
   Posted 5/16/2018 12:20 PM (GMT -6)   
Thank you all. In the Wikipédia tough ir says lorazepam is reduced with rifampin. Dont know i am trapped. Bactrim perhaps?

Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 32558
   Posted 5/16/2018 12:22 PM (GMT -6)   
isitlyme said...
Thank you all. In the Wikipédia tough ir says lorazepam is reduced with rifampin. Dont know i am trapped. Bactrim perhaps?


isitlyme - I did find information saying it could affect the lorazepam, edited my post...
but it won't let me past a link to the site.


IDK - what about a once daily dose of Rifampin? 12 hours later it's significantly reduced.

(by two half-lives)

What's your Dr. say?
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

isitlyme
Regular Member


Date Joined Mar 2018
Total Posts : 91
   Posted 5/16/2018 4:10 PM (GMT -6)   
Have to ask him, but does this mean rifampin is inducing the enzymes the whole time its on the blood?

Missouri
Regular Member


Date Joined Sep 2017
Total Posts : 335
   Posted 5/17/2018 7:38 AM (GMT -6)   
yes it greatly induces CP450 enzymes! Beyond that, it takes about 7-10 days for the enzyme to go back to normal after stopping the med. I would be very careful.

It may throw you into acute benzo withdrawal that may or may not go away by increasing your benzo dose. That is what happened to me with another medication. It was a very crappy week for me waiting for the CP450 to drop so my other meds would work and stop the withdrawal.

isitlyme
Regular Member


Date Joined Mar 2018
Total Posts : 91
   Posted 5/21/2018 6:58 AM (GMT -6)   
Missouri, wish benzo where you taking?

Missouri
Regular Member


Date Joined Sep 2017
Total Posts : 335
   Posted 5/21/2018 8:37 AM (GMT -6)   
Mine was not a benzo, mine was Kratom. An herb with mechanisms similar to a mild opiate.
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