New here, curious as to some interpretation of lyme blood test results

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Hammet89
New Member


Date Joined May 2018
Total Posts : 2
   Posted 5/20/2018 1:23 PM (GMT -6)   
Hey all. Pretty new here, I've been reading over the internet and what each band actually means on the IGM IGG western blots and what you supposedly do or do not need for a test to be considered positive. I've been having some interesting health issues the past year, all over the board of things happening. Anyway since there's probably some folks here with a good amount of experience, how concerned should I be if on my most recent lyme blood test band 23kd IGG, 41 KD IGG and 39 KD IGM bands came back as reactive
Thanks for your time

mpost
Veteran Member


Date Joined Feb 2015
Total Posts : 1522
   Posted 5/20/2018 2:31 PM (GMT -6)   
lymeaware.free.fr/lyme/Serologies/western-blot-bands.txt
/www.ncbi.nlm.nih.gov/pubmed/9163458

"The following interpretation criteria resulting in specificities of greater than 96% were recommended: for IgG WB, at least one band of p83/100, p58, p56, OspC, p21, and p17a for PKa2; at least two bands of p83/100, p58, p43, p39, p30, OspC, p21, p17, and p14 for PKo; and at least one band of p83/100, p39, OspC, p21, and p17b for PBi; for IgM WB, at least one band of p39, OspC, and p17a or a strong p41 band for PKa2; at least one band of p39, OspC, and p17 or a strong p41 band for PKo; and at least one band of p39 and OspC or a strong p41 band for PBi. The overall sensitivity was the highest for PKo WB, followed by PBi and PKa2 WB, in decreasing order. Standardization of WB assays is necessary for comparison of results from different laboratories."

so p39 as IgM can be positive. Does your WB tell you what strains were tested ? Afzelii Budgorferi Garinii ?

U have 2 bands that are reactive for IgG but they are not lyme specific as far as i know. Yet the fact u have two, plus p39 as IgM is highly suspicious and may be enough for some LLMDs to try treat u.

Do u have symptoms of any kind ?

I'd contact an LLMD and see if he is willing to treat you. But if u have zero symptoms and do not remember a recent tick bite, then i would not treat. So unless u were bitten recently, if that is the case then you should get treatment since this is your chance to get rid of it before it spreads in your body.

But otherwise, we all want to reach some sort of homeostasis (equilibrium) with the bacteria, where we have minimal/no symptoms and not necessarily eliminate it, since that is not always possible. so if u have no symptoms, just based on a test, i dont think it's a good idea to bombard yourself with antibiotics ...

Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 32608
   Posted 5/20/2018 2:50 PM (GMT -6)   
Hammet89 said...
Hey all. Pretty new here, I've been reading over the internet and what each band actually means on the IGM IGG western blots and what you supposedly do or do not need for a test to be considered positive. I've been having some interesting health issues the past year, all over the board of things happening. Anyway since there's probably some folks here with a good amount of experience, how concerned should I be if on my most recent lyme blood test band 23kd IGG, 41 KD IGG and 39 KD IGM bands came back as reactive
Thanks for your time


Hi Hammet89, welcome!

Bands 23, 39 are both specific to lyme.

Here is a questionnaire you can do - Dr. Horowitz (well-known lyme Doc) devised it - showing the 'likelihood" that the symptoms are due to lyme

lymeontario.com/wp-content/uploads/2015/03/Horowitz-Questionnaire.pdf

You could share what your symptoms are with us...


"We need to teach doctors how to make a clinical diagnosis of Lyme disease after ruling out other diseases, supporting that diagnosis by finding borrelia-specific bands on the Western Blot, which show evidence of exposure. This would include finding the 23(OspC), 31(OspA), 34(OspB), 39, and 83-93 kDa bands on the Western Blot. "

(per Dr. H interview)
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

Post Edited (Girlie) : 5/20/2018 2:53:21 PM (GMT-6)


Hammet89
New Member


Date Joined May 2018
Total Posts : 2
   Posted 5/20/2018 3:18 PM (GMT -6)   
Hey all, thanks for the replies, symptom wise I've been all over the place the past year. A lot of my symptoms seem to be of neurological in origin, tingling in various parts of the body, lower back pain, pain in the arms, eye pain, nystagmus ,balance issues, ear pain, neck pain, some vestibular issues, a lot of brain fog, nausea, dry heaving, blurry vision, digestive issues, seems like I get winded when I could exercise a lot quicker than usual (like just walking up the stairs would raise my pulse way more than it should). I've had cardiac tests to rule out all of that stuff. The tough part is there's a lot of overlap with my symptoms of other conditions. When the neurologist saw the lyme results, he didnt seem to concerned, he ruled out ms too. Light and sound sensitivity as well I have. I'm pretty limited when it comes to living life right now. Currently cant work/drive/go out. I've had a couple instances in the past year where I was just standing or walking, and all of a sudden my vision was all spotty and i almost felt like i was going to pass out. I've had a lot of emotional issues that stemmed.from all of this. Normally I'd be more inclined to not say all of this was lyme, but my condition has gotten dramatically worse over the past 7 months or so, as compared to before that when I didn't feel great, but was still functional. The developing of new symptoms without doing anything to cause them is what has me concerned that there's something else going on aside from something like all of this just stemming from a vestibual issue or something else alone. And when I researched the bands that were positive on my lyme it gave me cause for concern.

BungalowMo
Regular Member


Date Joined May 2018
Total Posts : 21
   Posted 5/23/2018 4:09 PM (GMT -6)   
Yeah...my results on the Horowitz test...86.

Doesn't surprise me a bit! sad

Just got my blood tests back today. Reactive on 41 IGG & 23 IGM. According to Quest, I'm Negative.
According to my body...full blown.

Waiting to hear back from my LLMD. I REALLY wanted the IGENEX. I may still request it. Why not, it's MY $$.

Post Edited (BungalowMo) : 5/23/2018 4:13:59 PM (GMT-6)

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