Yes, have absolutely run into this problem. It's part of the reason I was misdiagnosed for over 9 years with CFS/ME. I try not to dwell on the subject of this whole denial of persistent lyme problem because it really upsets me. I don't need to convince people of the reality I'm living.
There are studies out there showing persistence of borrelia after lengthy abx treatments. Dr Liegner has a big book and he documented some of his cases, including spinal taps that showed active borrelia in patients he had treated for many years.
There's a list somewhere online documenting a multitude of studies looking at the persistence of borrelia. I'm unable to track it down right now, I'll see if I can find it at some point.
(edit) Found it! /www.ilads.org/wp-content/uploads/2018/07/CLDList-ILADS.pdf
Post Edited (sebreg) : 8/15/2018 3:03:18 PM (GMT-6)