If you follow the work of Dr. Robert Naviaux - he did a small trial of Suramin for autism patients and the results were good. Some non-verbal kids spoke sentences for the first time in their lives.
Suramin, which is a 100 year old drug, treats river blindness and african sleeping sickness. According to Naviaux, he believes the drug is working by halting the Cell Danger Response due to its anti-purinergic properties.
Here's a bit about
Cell Danger Response as it could apply to us Lyme patients: The cell danger response (CDR) is an evolutionarily conserved cellular metabolic response that is activated when a cell encounters a chemical, physical, or microbial threat that could injure or kill the cell. Common microbial threats are viruses, bacteria, fungi, and parasites. Physical threats include heat, salt, or pH shock, or UV or ionizing radiation. Chemical forms of danger include heavy and trace metals like lead, mercury, cadmium, arsenic, and nickel, certain electrophilic aromatic chemicals like the plasticizer bisphenol A, the chemical flame retardants like the brominated diphenyl ethers (BDEs), and certain halogenated pesticides like chlorpyrifos and DDT. Psychological trauma, particularly during childhood, can also activate the cell danger response, produce chronic inflammation, and increase the risk of many disorders (Ehlert, 2013).
The CDR being stuck "on" could be cause of many chronic diseases. I guess you could argue that for Lyme disease, the CDR continues because of persister bacteria.
Klinghardt treats autism and lyme the same way. His new protocol (which treats retroviruses) includes a homeopathic suramin. I am self-treating at the moment as I wait to get in to a Klinghardt trained doc. I'm taking the homeopathic suramin and have noticed an improvement in sleep and in general feeling better. /www.sciencedirect.com/science/article/pii/S1567724913002390