An interesting drug candidate identified in the study was the alcohol dehydrogenase inhibitor, disulfiram
Though the drug is used as a treatment of alcohol abuse, recently its anticancer potential has also been discovered. It has been known to make complexes with metal ions and cause the disruption of the proteasome, leading to death of the cancer cells.
Similarly, the metabolites of the drug molecule have been known to significantly inhibit the growth of a number of bacterial species, including the biofilm-forming Pseudomonas aeruginosa.
The drug molecule has a good bioavailability
, and it passes the blood–brain barrier
to show its effect in the central nervous system. Though most of the studies are concerned to the use of the drug molecule in alcoholism yet, being a safe, FDA-approved molecule, the drug can be repurposed for its antibacterial potential.
Post Edited (Rainy cloud) : 10/4/2018 12:35:42 AM (GMT-6)