Drinking large amounts of hyaluronic acid has really helped my joint pain.
The only way to do this is to buy the pure HA bulk powder and mix it with some water. Trying to take large amounts using supplement capsules will break the bank.
Basically I just put about
200 mgs in some water, wait for about
1 hr for it to gel up then drink it down. YOu can also mix it up and let it sit all night if you want to. Really seems to help ease my joint pain noticeably. Am also taking collagen 5 gr/day, glucosamine hcl 3 gr/day, but neither of those has had the noticeable lessening of pain like HA has.
This study showed that lyme depletes HA production by the cells quite a bit: 40% - 60% less HA when the lyme bug is present. Also notes the inflammatory cytokine IL-6 production is higher with lyme.
Borrelia burgdorferi decreases hyaluronan synthesis but increases IL-6 production by fibroblasts
Despite the prevalence of clinical data on human Lyme disease, little is known about the immunopathologic effects of the causative organism on the host. We studied the effect of Borrelia burgdorferi on hyaluronan (hyaluronic acid, HYA) production and the effect on interleukin-6 (IL-6) synthesis by cultured fibroblasts. The cell line employed in this study produced an average of 1406 ng of hyaluronan/ml within 48 h. Using both a morphological staining protocol and a quantitative radiometric assay, we noted that in the presence of a low dose of Borrelia (9.4 × 105 cells/ml) the hyaluronan production decreased to an average of 1008 ng/ml, a significant difference (p < 0.05) from the amount of hyaluronan produced by the cells alone.
The reduction was even more significant (p < 0.01) when a higher dose of Borrelia (9.4 × 106 cells/ml) was used giving an average hyaluronan concentration of 682 ng/ml. In contrast, we found that Borrelia stimulated the cells to produce IL-6 from a baseline of 293 pg/ml to a maximal value of 842 pg/ml (p < 0.01). The spirochetes had no significant effect on cell viability, nor were we able to demonstrate invasion of the cells by the bacteria. Both a decrease in hyaluronan and an increase in IL-6 may correlate with the pathogenicity of Lyme disease in man.
Post Edited (Lapis_29) : 6/12/2019 9:09:42 AM (GMT-6)