Neil Nathan notes on MCAS at recent Iseai conference:
Neil Nathan, MD spoke on "Elephant in the Room: Mast Cell Activation" and shared:
Concussion or whiplash can lead to cervical trauma Fibromyalgia. Causes a persistent inflammation of the spinal cord which is treatable with FSM. Can take a whole layer of inflammation out of a patient. Single treatment can reduce pain and symptoms by 50-80%.
At least 50% of his patients have Mast Cell Activation Syndrome.
Mast cells are a bridge between the immune and nervous system. Direct neurological connection to the vagus nerve.
Mast cells have many contents beyond histamine including serotonin, serine proteases, and others.
VEGF and TGFb1 are significantly made by mast cells.
The role of mast cells is to coordinate the immune response to infections and toxins.
In genetically susceptible individuals with exposure to specific toxins, mast cells may become activated.
MCAS symptoms often appear within minutes after eating; can even be triggered by water.
Has had about
250 patients that did DNRS with "fabulous success".
Localized edema can be MCAS.
Difficult to get MCAS tests done properly; need a cold centrifuge and need to catch a snapshot when the MCAS is fired up. Without a refrigerated centrifuge, 5% of histamine is all that will be captured.
Can make a MCAS diagnosis without positive testing; treat it.
Treatments are largely benign; not treating leaves patients to the winds of fate.
It is not a lifelong issue to have MCAS.
Trigger is almost always mold, often Bartonella, sometimes Lyme.
Many of his MCAS patients are cured.
Quercetin 250-500mg 30 minutes before each meal and at bedtime can be very helpful.
Loratadine as an H1 blocker and Famotidine as an H2 blocker may be used; can use Zantac.
50% benefit from a low-histamine diet.
NeuroProtek LP, ADO, AllQlear (tryptase inhibitor), Perimine, PEA/Mirica may be used.
Fexofenadine, Ranitidine, Ketotifen, Cromolyn may be used.
The more you do, the quieter the mast cells, the better the course.
Claritin or Allegra are patient favorites.
One of his favorites is Ketotifen; H1 blocker, leukotriene inhibitor, and mast cell stabilizer.
"If some is good, more is not necessarily better."
Working on the limbic system also works on MCAS.
Back up and treat the vagus nerve and limbic system first. Then can treat mold, Lyme, and other issues more successfully.
Here’s the full link:http://www.betterhealthguy.com/iseai2019?fbclid=iwar3lyi-i37v20cbyqegrlzko9pza0dxeeicecxmdrxbxeo6e9l7txmr11qo
Post Edited (k07) : 5/28/2019 12:11:50 PM (GMT-6)