Somewhat Skeptical said...
The Lyme diagnosis is for a 72 year old female who was diagnosed with Rheumatoid Arthritis within the last year and was diagnosed with Fibromyalgia approximately 15 years ago. Within the last six months, she has developed chronic dizziness/lightheadness, extreme fatigue, difficulty thinking clearly, and hand tremors which come and go. An MRI showed white matter lesions that were not present in an MRI from seven years ago, but subsequent analysis of her cerebrospinal fluid and evaluation by a neurologist turned up no evidence of any major neurological problems. Her primary care doctor, however, has diagnosed her with late stage Lyme disease and prescribed two months of IV antibiotics based on the following results from her CSF testing:
*All 10 IgG bands Absent
*P41 IgM Absent
*P39 IgM Present (A)
*P23 IgM Present (A)
...and a Protein Electrophoresis/Immunofixation A/G Ratio of 1.3
The patient has previously had two ELISA tests (one by this particular doctor several years ago and one by her rheumatologist within the last year), both of which were negative. Given the across the board negative IgG antibody numbers, the fact that RA is known to create false positive results in IgM, and the fact that IgM tests aren't typially used to diagnose cases where the symptoms have been present for more than 30 days, I'm skeptical of the diagnosis. Am I missing something?
I’ve not heard that RA can cause false positives for lyme??
And that is not correct that positive IgM isn’t used to diagnose lyme for symptoms over 30 days.
I was IgM positive 14-15 months after symptoms started... many of us get a positive IgM years later.
Dr J (well known LLMD ) wrote that a late IgM positive represents a continuing reactivation of the infection.
Elisa tests aren’t good tests.
As jb1994 stated - 2 weeks of abx won’t be enough.
I recommend she seeks out a Lyme Literate dr
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi