ncbi studies say this about
the mechanism of action:
"Disulfiram irreversibly inhibits aldehyde dehydrogenase (ALDH1A1) by competing with nicotinamide adenine dinucleotide (NAD) at the cysteine residue in the active site of the enzyme. ALDH1A1 is a hepatic enzyme of the major oxidative pathway of alcohol metabolism converting ethanol to acetaldehyde. At therapeutic doses of disulfiram, alcohol consumption results in increased serum acetaldehyde, causing diaphoresis, palpitations, facial flushing, nausea, vertigo, hypotension, and tachycardia. This aggregation of symptoms is known as the disulfiram-alcohol reaction and discourages alcohol intake. The reaction is proportional to both the dose of disulfiram and alcohol. Disulfiram is not an anti-craving drug and does not modulate the neurobiological mechanism of addiction"
This makes me nervous because the major byproduct of candida is acetaldehyde and that's a major problem for me & lyme folks. If disulfiram blocks your bodies ability to detox alcohol, could that be part of the reason for why people feel so crappy on it?
I always get leary when people suggest anytime you feel worse, it's die off. I've had many adverse reactions to medications but rarely ever die off. For instance, Flagyl screwed me up bad but it wasn't die off. Dr J (Rockville) said that's clearly an autoimmune reaction and he uses Flagyl to judge that in people. I know the mechanism in which disulfiram works for lyme is unknown but could some of the intense reactions to it be borne out of other means? I'm going to take it in the dose recommended but I am a bit nervous about
Post Edited (Aerose91) : 10/22/2019 5:40:29 PM (GMT-6)