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How long does disulfiram take to show effects

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Posted 12/3/2019 8:20 AM (GMT -7)
I'm only 2 weeks in now and 1 week on 250mg/day. I'm wondering how long until a typical person may feel effects? I also understand I'm atypical

Everything I've seen says that DSF doesn't kill bartonella, is that still true? Quite frankly the only infection that has given me notable die off and that had any response to medication is bartonella. My condition didn't change afterward but it was still way more of an reaction than anything I've had to lyme or babesia. Wondering if a year of treatment with Dr M killed it off or if it's still lingering around
Posted 12/3/2019 8:33 AM (GMT -7)
It has a delayed effect, but I was herxing after 2 weeks.

My experience was that it seems to stir up the bartonella but not kill it. I found that the bartonella would become active and I'd get itchy, then if I took minocyclne I would get the typical bartonella herx (dark urine, painful bloated abdomen).

Are you taking anything else for bartonella or just disulfiram?
Posted 12/3/2019 8:42 AM (GMT -7)
I just had my first herx, a bit more of a headache than usual today. A bit less sleep. It's been 2 weeks since I started.

I had a course of bactrim a month ago and it didn't do anything for me, it was for sinusitis but I know it stirs up bart. I'm hoping that I do not have it.

I definitely noticed a difference when I started taking it at 62.5mg a day. I'm at 187.5mg now. I'm pretty sure it's working well.

Also the lyme reproductive cycle is when a lot of die off occurs as well. So that's around every weeks or so.
Isaiah 54:17 No weapon formed against you shall prosper
Jeremiah 29:11 I know the plans I have for you, plans to prosper you and not to harm
you, plans to give you hope and a future

UnsightlyCignet
Posted 12/3/2019 10:37 AM (GMT -7)
Everything I've seen and read also says that Disulfiram doesn't kill Bartonella, but I'm not sure how this has been established as there hasn't really been much research into DSF for Bartonella. As ever, it's all fixated on Borrelia for some reason.

I started getting a herx or some kind of reaction to Disulfiram after about 3 or 4 days even at a low dose, but I honestly don't know if it was actually a herx or just bad reaction to the drug. It's so hard to say because I ended up having to stop because of the neuropathy it gave me. That has kind of made me question whether any of the things that happened when taking it were due to it killing pathogens or just the DSF messing with other things.

I am beginning to think that most of my problems are caused by something other than Borrelia and if I do still have it, then it's only a fairly mild infection. By all accounts Bartonella seems to be a far more devastating and difficult to treat infection and most of my symptoms are attributable to that.
Posted 12/3/2019 11:13 AM (GMT -7)
Thanks, guys.

Quin- I am currently on disulfiram and doxy. Nothing particular for bart. Even though I've treated it for so long I'm still not sure if it cleared since my immune system and all....

I may get some houttoniya and add that in to see if I elicit a response. that would be telling

After a year and a half of treating bart with Dr M he said I've cleared it but who the heck knows at this point
Posted 12/4/2019 10:41 AM (GMT -7)
Wondering how you’re doing Aerose?
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi
Posted 12/4/2019 11:44 AM (GMT -7)

Aerose91 said...
Thanks, guys.

Quin- I am currently on disulfiram and doxy. Nothing particular for bart. Even though I've treated it for so long I'm still not sure if it cleared since my immune system and all....

Bartonella is usually susceptible to doxycycline, so it's not surprising you might get a herx from that, especially if you're disturbing the dormant cysts with disulfiram.
Posted 12/4/2019 4:40 PM (GMT -7)
Hey Girlie- I'm having a little more anxiety and adrenal crashes this week. I'm not sure if I can pin this on the disulfiram or maybe I ate something off? Plus it seems like lots of people are having anxiety this week so I'm not sure what I can relate it to. Hoping there's a chance that DSF may have some effect on bartonella if I do still have it!

How are you feeling? You've had a rough past few weeks.
Posted 12/4/2019 5:07 PM (GMT -7)
I just asked about this too. I have had a relapse of bartonella and after a course on Rifampin and Septra my doc wants to put me on disulfiram. She’s said there’s evidence that it works against persistent bartonella as well as Lyme. Theories appear to be mixed but she’s always steered me right in the past so we will see. I’m going to hold off until after the holidays though. For my own sanity!
Currently in remission from a 20 year infection with Lyme, Bartonella, Babesia, MARCONS, Myco, EBV, etc...
Posted 12/4/2019 9:25 PM (GMT -7)

ChickNorris said...
I just asked about this too. I have had a relapse of bartonella and after a course on Rifampin and Septra my doc wants to put me on disulfiram. She’s said there’s evidence that it works against persistent bartonella as well as Lyme. Theories appear to be mixed but she’s always steered me right in the past so we will see. I’m going to hold off until after the holidays though. For my own sanity!

I would love for this to be true
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