I know she tested positive for Lyme, Ehrlichiosis, Rocky Mountain Spotted Feve and two more, I will ask her when she gets home from work.
very few herbalists believe these bugs build tolerance to herbs.
treatment for these organisms is also highly variable from person to person with often lots of trial and error needed to find what works for each individual.
your friend has multiple co-infections making this particularly so.
so it may be the best course of action simply to stick what has worked well for them to date - just gradually reduce the dosage.
for Lyme I think Japanese knotweed is another good option - it is what is termed a food-grade herb and eaten as a food in many countries - so can be taken long term without ill effects.
it is both anti-inflammatory for the exact inflammation caused by Lyme and the latest research shows also directly anti-spirochetal.
Stephen Buhner now recommends - Dan Shen ( AKA red sage root/ salvia miltiorrhiza root) tincture for pretty much all chronic bacterial infections - as it is an immune adaptogen.
it is the most widely consumed Chinese herb in china and also very safe to use long term.
Since they are all bacterial infections - this would be another good choice for maintenance.