> then you dosed heavily with Vit D3 - you could have an immunosuppressed episode
Yes, super bugs seem to be smart enough to shutdown active pathways of D3 effectively making supplementation as well as D25 levels primary immunosuppressive by leaving only anti inflammatory part of D3/D25 intact (via VDR expression decrease)
> Then, if you manually raise the Vit D levels too high, the body suffers
> from immune suppression because the receptors are unable to use the
> Vit D properly. Is this right?
Yep, raised levels of Vid D are immunosuppressive by themselves but VDR activation through D25 active metabolite(D1.25) counteracts this still leading to potential benefit of D. The problem is in superbugs that decrease VDR _expression_ making the whole Sun/D3->D25->D1.25->VDR pathway chronically dysregulated.
There are a lot of studies of the potential benefits of D3 supplementation - the main problem is that researches do not take into account the effect of bacteria on the VDR receptor.
BTW, not only lyme suppresses vit D pathways, but also EBV, CMV, aspergillus, and even M leprae:
Upon infection of monocytes with M. leprae, there was no upregulation of CYP27B1[CP27B] nor its enzymatic activity converting the inactive prohormone form of vitamin D (25-hydroxyvitamin D) to the bioactive form (1,25α-dihydroxyvitamin D).
Infection of IL-15-derived MΦ, similar to macrophages in lesions from the self-limited form of leprosy, with M. leprae did not inhibit induction of the vitamin D antimicrobial pathway.
These results indicate that M. leprae evades the intrinsic capacity of human monocytes/macrophages to activate the vitamin D-mediated antimicrobial pathway via the induction of type I IFN
More broadly, our findings suggest that the clinical management of mycobacterial disease using vitamin D supplementation will require simultaneous management of the vitamin D metabolic system to achieve therapeutic benefit.
Post Edited (Dmitry) : 10/18/2020 4:35:09 PM (GMT-6)