excess glutamate help

Need some help on glutamate excess. For 2y I got "vestibular migraine", which felt like dizziness, head zaps, tightness in the back of my head, and vertigo. My dr at the headache institute of ny postulated that since they seeemed "seizure-like", it might be excess glutamate, so we tried gabapentin and they went away. Havent gotten one in a long time.

A month ago I stared a soup diet, inflammation is way down. But the past 3 days, I've started to get that dizzy vertigo feeling. I'm also on a new supplement regimen.

But the odd thing is, every supplement on i'm seems to indicate that it helps glutamate excess.

Creatine - supposed to help glutamate
NAC - Attenutes glutamate
CoQ10 and L-Car - Both protective to glutamate
Fish oil and turmeric - both protective to glutamate
BPC157 - used to heal gut lining, big question mark
B2 - unclear

So my question is, if my inflammation is lower - > less oxidative stress -> less glutamate. I'm on plenty of vitamins that are supposed to lower glutamate. I feel healthier than ever. Why now? Is it the BPC? Def going to cut that out and see. Is it the fact that I've gotten my methy-cycle going possibly? Is it the paleo diet?

Need someone who understands glutamate and possibly methylation.

I took this product before bed for a bit:
https:// https://professional-health-products.com/product/glutamate-scavenger-3/

I took another one called glutamate scavenger 2 in the morning.

They were suggested based on my genetics (Bob Miller - Tree of Life).

I posted on another thread about NMDA replacing glutamate in the brain causing dysfunction.Check into that too.

Thanks k07! I'm going to order some of that and try it.

Basically, I think my excess glutamate years ago was do to multiple things. 1.) Unhealthy lifestyle. Going out to much and eating awful food. The more oxidative stress you have, the more the CBS pathway needs to be upregulated to produce glutathione. An unfortunate byproduct of that is glutamate 2.) some form of autoimmunity 3.) I do have low titers of the GAD65 antibody, which may inhibit my ability to break down glutamate, assuming the antibody is actually active 4.) I have some weird SNPS in my genes related to GAD1, which helps break down glutamate. Image attached. Cant seem to find any information on these SNPs tho, but I do have the risk alleles.

https://ibb.co/1rppq46

But...I'm wondering if my issue right now is the fact that I've been living on animal protein (and fat) for the past month. It seems that high protein diets naturally cause ammonia levels to spike. If there's too much ammonia the body creates glutamate which combines w/ the ammonia to turn into glutmamine. Aniamal protein and soup broth is also super high in glutamic acid. Who knows but its one idea. Might have my blood ammonia levels checked.

The only thign that has worked for this in the past was gabapentin, but that caused other problems.

Going to try some Yucca and ornithine to normalize ammonia levels.

Post Edited (dcd2103) : 11/4/2020 5:41:36 AM (GMT-7)

You're welcome dcd! I am just figuring out that this may be my issue so I have not tried any of the supplements yet but was thinking of trying yucca first. Do you feel depersonalized that is my biggest symptom? Glad the article helped

My ears started ringing today and felt like I was gonna pass out. Finally i pulled out my glucose meter forgot I even had one and my blood sugar was 53. Feel kinda stupid, but it felt exactly like the vestibular migraines I had for 2y. So far looking like that could be it

I dont know anyone who has tried it, but I will give it a shot.

My blood sugar got down to 53 tho, and I heard ringing and was about ot pass out. I can only assume that must actually be what did it. I felt better after i ate a few raisinettes to raise my blood sugar, but now today I'm getting it a little bit again. That's how my brain is, once glutamate excess is triggered I get the same migraine for a week.

Def caused by the drop in bloodsugar tho. I was probably hypoglycemic for 3 days straight.

"Pathophysiological mechanisms responsible for neuronal cell death in hypoglycemia include the involvement of glutamate excitotoxicity. Severe and prolonged hypoglycemia results in increased release of glutamate in the brain, leading to membrane depolarization."

Dr J told me to take LOLA for ammonia.

L- ornithine - L- Aspartate

Dcd, I'm glad the Ashwaghanda helped you, I found the info online,thought you might be interested When ammonia levels get very high a person will start developing high glutamate levels. This will cause a head ache that will make your head feel like it is going to split in half. Dysbiosis, high glyphosate or glufonisate levels in the body can cause high ammonia levels. Infections can also increase ammonia levels, especially tick born illness. High aluminum levels causes a disruption in the cycle needed to convert glutamate to GABA. This causes low GABA levels and high glutamate levelS.

Your welcome. No I have not been tested. I am trying to find a doctor who will do these types of blood test for me. Anytime I find info on the subject I will post it for you.