Another one here:
"Our study showed that the levels of activated microglia and the inflammatory cytokines (TNF-α, IL-1β, IL-6, and IFN-γ) in the spinal cord tissue increased after the SCI, which were linked to the BSCB permeability and the neurological function scores. The inhibition of HDAC activity following the VPA treatment promoted the phenotypic shift of microglia from the M1 to the M2 phenotype, as well as inhibiting microglial activation and reducing the expressions of inflammatory cytokines in vivo
. The NF-κB is considered to be the central transcript
ion factor of inflammatory mediators, where it plays a crucial role in inflammation [8, 9]. The VPA treatment significantly weakened the NF-κB p65 nuclear trans
location and its transcript
ional activity following the SCI, which showed that the VPA exerted neuroprotective effects."