Hmm i've tried black walnut and berberine for parasites. Similar to GSE and oil of oregano, they both flared me. I think they ramp up the immune system. I've not had much success with herbs, antioxidants or mushrooms, which is kind of why ivermectin intrigues me.
dcd - my symptoms also flare dramatically on berberine - this is interesting to me as berberine is not well absorbed - in fact 90+ % of it stays in the gut - and what little does get through first has to go to the liver which will further filter it out before it can get to the systemic circulation - so unless you take huge doses it seems unlikely for there to be enough getting into our systemic circulation to kill microorganisms there to cause flares by that mechanism.
i would flare on berberine herb tinctures alone - in small doses - eg 10 drops 3x a day
this leads me to think that in my case the effect is mediated by killing microbes in the gut only (since it doesn't get into systemic circulation) - perhaps leading to more inflammatory by products entering the system via hyperpermeable gut membrane - or maybe even just interacting with the immune cells in the lumen itself ( they say 70% of the immune cells live in the lumen ).
in my case anything that results in more bacterial activity / material in the gut causes this same type of reaction
-adding probiotics - introduce new bacteria / kill some existing bacteria via competition = more by products
-adding prebiotics - grow more of existing bacteria = leading to more bacterial by products
-taking antimicrobial herbs - kill bacteria => more by products
-taking antibiotics - kill bacteria => more by products
whereas things that reduces bacterial material in the gut reduces overall symptoms
-low carb diet / keto diet
interestingly - and consistent with the above - if i ramp up slowly with antimicrobial herbs i can minimise the herx effects and get to a point where i can take 5-10x the dose that would flare me in the beginning - and symptoms/function is v gradually improving - perhaps by reducing the quantity of bacteria in the gut in general over time - while avoiding big step changes in bacterial by products to flare the system.
this is a complex disorder with many layers - and i think this bacterial sensitivity (probably even to by products of normal commensals) is a downstream problem caused by infection / long term inflammation in the gut in my case.
I have plenty of lab markers to support that gut inflammation exists - in my case i think its ongoing infection that is the driver - both lyme and bart are demonstrated to infect gut tissues - and the symptoms pattern and lab testing all seem to fit with this best - so in my case at least that's my working theory.
it is exactly this immune dysregulation aspect - where the sensitivity knob is dialled all the way up in the gut - that i hope ivermectin may be helpful with - it is known to down regulate the TLR2 and TLR4 pathways - which are the ones that our bodies use to drive inflammatory responses to bacteria in the gut - so - there is a rational basis - but ultimately it is a trial and error exercise.
just hoping to gather a little more on the specific of how best its used in lyme patients before i start - but this is very thin on the ground it seems....