quick update for those following this:
i started my trial with Ivermectin on Thursday
i took a half a 12mg dose - so 6mg - with a fatty meal ( better systemic absorption ) around 3pm
no apparent side effects or notable positive changes from the half dose
possibly a few extra aches and pains in hips on evening walk last night - but think that was just stiffness from washing the car the day before
sleep was a bit more disturbed in the night with frequent waking and some heart mild palpitations - but - again this has been a feature recently and typically up and down with some nights worse than others so I doubt its connected
felt pretty decent next day - up 7-45am and doing stuff like light chores from around 9-30am - but again nothing remarkable - within the normal variation i have day to day
half life is around 1 day - but metabolites seem to stay active in the body long term - and so presumably these are responsible for the immune modulating effects.
think any severe effects are most likely in the first 24hrs so added the second half dose Friday at lunch also - again - no obvious effects.
had a v busy afternoon - working outdoors on manual stuff for about
4 hrs - then felt i had overdone it as got v tired and achy, with increased focal headache etc - but again this is pretty standard for me.
this kind of overdoing it used to lead to pretty severe PEM. usually worsening next day.
but more recently in the last 9months of so i can do more and get no PEM or just mild PEM.
in this case it did not get any worse after i stopped - so again much the same as i would have expected for my current state of health. slept well. am OK today
so - in conclusion - no ill effects i can determine - no herx effect at all that i can detect. Everything seems within normal limits of variations i experience day to day anyway.
but also no obvious short term wonderous effects that we tend read about
in some anecdotal accounts.
however the metabolites stay active in the system for a long time, and modulating the immune system is typically a long term undertaking, so it is probably too early to tell if there will be long term benefits.
for now - consider this very preliminary findings - mainly - nothing bad happened.
we still don't have good info on the best dosing regime for Lyme as immuno-modulator ( so please do post any information or experiences you find) but i plan to keep going on a 1x per week basis for at least a couple of months, which i hope will be long enough to see any possible positive effects, and will update here in time.
Post Edited (Garzie) : 5/15/2021 4:56:09 AM (GMT-6)