most of the stuff i have read on bartonella forming drug resistance has said that it definitely does happen - and relatively rapidly in the lab. its documented a few weeks i think.
but in the lab things are very different than in the human body - in the lab these tests are done in vitro - ie in a petri dish in culture mediums that are v different to human tissues - the bacterial reproduction times are much faster and and i think they kind of force the process - take a culture of growing bacteria - treat with a single ABX at a concentration known not to kill 100% - and after a while take those that survive and grow them back up in numbers in fresh media - then rinse and repeat till you have selected those with resistance genes.
This demonstrates the principal that the organism can develop single antibiotic resistance (not all pathogens do - borrelia for instance have never to my knowledge been demonstrated to do so) - however because the lab method is designed to make this happen quickly as possible - its likely that in humans this is all happening much much slower.
in addition the normal method to prevent antimicrobial resistance is to use 2 or more antibiotics from different families at the same time.
from your account you did not seem to use only a single antibiotic for any length of time and so on the face of it, it seems less likely that you would have cause resistance to develop.
i have not seen much data on which combinations of abx are the most effective for preventing resistance - or specific effectiveness for preventing resistance of all available combinations involving doxy / minocycline - and suspect this data does not exists - so its more of a general principle.
if it has developed resistance to clarithromycin, i would expect the resistance mechanism that has developed for clarithromycin to work for azithromycin also as they are in the same family and v similar indeed in composition and action - their main difference seems to be in pharma kinetics - one is present more in the tissues and the other in the plasma.
Post Edited (Garzie) : 5/10/2021 10:03:11 AM (GMT-6)