its on the fringes of what has been researched
but while the above general rule applies for a lot of conventional simple infections - it doesn't seem to hold true for all of them - especially chronic infections - and in particular where lyme is involved
as testament to this - in the UK there is a government run specialist lab - a kind of centre of excellence for infectious disease testing and research - called Portland Down - this is where they send all samples suspected of anything new or "unusual" for confirmation testing - i had a bunch of different tests done there after pushing my GP for referral to an infectious disease specialist - anyway, all of the tests for anything that sits in the lyme co-infection category - like spotted fever rickettsia, Q-Fever, typhus - all carried the following report comment
"Report Comment Serological testing in cases of malaise that have lasted more than 6
months is unlikely to be useful."
i know these are not viruses - i just wanted to illustrate the principle that its quite well known in the circles where people have actual knowledge of this stuff - and are not just quoting 30yrs old text books (as most GP's do) - that serological testing for chronic infections is not reliable - and does not tend to follow the same rules as simple acute infections.
where lyme is involved - I'm assuming you have a lyme diagnosis here - there are plenty of reasons to suppose it can significantly effect part of the immune systems function towards other infections.
we know that lyme definitely hinders the bodies ability to produce antibodies to the lyme organism itself - and where for instance the mechanisms used by the lyme organism are general immune suppressive or immune disruptive in nature - there is good reason to believe that it also interferes with the body's ability to produce antibodies to other infections. for instance there is research in monkeys with lyme that showed that it infects the "germinal centres" of white blood cells and stops them functioning properly.
so one possible explanation for the lack of typical antibody patterns in chronic illness is that lyme, if present, has disrupted normal antibody production -
bottom line - serological testing ( tests based on antibodies ) for chronic infections of any sort is of limited value - and particularly so where lyme disease is involved or highly suspected.
that said - Very high titres of either IgM or IgG could still have diagnostic or suggestive value and would bear further investigation.
Post Edited (Garzie) : 8/28/2021 4:15:30 AM (GMT-6)