WBF, could you elaborate what the symptoms of MCAS are? I have cetirizine on hand, and I have used it but it does next to nothing. It just makes me feel a bit drowzy, ironically as it was a solution to sleep inducing antihistamines.
The symptoms I have that I associate with MCAS are burning in the tops of my feet, burning and numbness.
My Zyrtec is 10mg. I break it in half and take 1/2 in the morning and 1/2 at night. It takes a few days to a week for your body to adjust to antihistamines. Consistency is absolutely key to knowing if it will help any symptoms. You can’t miss a dose. It needs to stay in your system like clockwork. The daytime sleepiness May disappear if you take it consistently.
Saraeli seems to be the most knowledgeable on MCAS. See her comments on this post: https://www.healingwell.com/community/default.aspx?f=30&m=4226129
Today, I was reading the transcript
of an interview that BetterHealthGuy did with Neil Nathan and 2 others in Dec 2020 regarding mycotoxins. Here’s the link: https://www.betterhealthguy.com/episode122
MCAS came up in the conversation. At 01:25:29.26, Beth starts talking about
MCAS. What she said made me think of you and how you have just gotten worse and worse no matter what you’ve done. I pasted those paragraphs below and highlighted a comment that surprised me.
“ And what happens is those mast cells, one they have over a thousand receptors on the outside, they're pretty fascinating cells. And so any kind of toxin can trigger one of the toxin-related receptors, then those mast cells are going to start releasing their different inflammatory compounds. And that can set off a mast cell cascade, where you have a few localized mast cells reacting, setting off this cascade inflammatory compounds, mediators and then that's triggering the surrounding mast cells.
They start to release inflammatory compounds, trigger's the surrounding ones, and that can keep going. Kind of like a forest fire starting with a spark and then eventually burning out of control.
These mast cells live over a year, they're very long-lived cells and if they get dysregulated from this excess toxicity being pushed through the body, then they can stay dysregulated for quite some time.
And this is why taking this approach of calming the mast cells initially, and then going very slowly and implementing the protocol is so critical. And you can actually move people so much quicker because if you get them into a six-month flare, you're not going to get anything new onboard until that comes back down.