thanks Rainy, it was a term i picked up from the researches looking into the behaviour of Lyme persisters and other persister cells - so not my concept.
it seems its been in use for some time - perhaps for mammalian cells also - basically all work cells do - whether to change their shape, produce energy, make chemicals etc all has a metabolic cost - and all cells have only so much resources and limited ability to replenish them.
the daptomycin trials do seem to suggest that it might be possible to wear the spirochetes down - and therefore repeated hyperthermia treatments might also do that.
I'm not sure if we have complete information on how long the spirochetes take to move from one state to another and how long to wake up again in between.
if you stress them too frequently - they would just not come out of their dormant phase and remain unsusceptible - and if too infrequently - they would have time to recover their resilience in between - so there is likely a "Goldilocks frequency" - not to often or to infrequent that gives them optimum stress.
perhaps the daptomycin trials can shed some light on that - i don't recall the timing of that one. i seem to remember other similar trials on persisters used 5-6days i think.
Thank you very much Garzie.
Yes that's a problem for sure, if they were to stay in dormant phase and just not come out anymore.
Or maybe then they would be more susceptible to drugs that target that form, specifically... hmm.
lol it's like some strange battle we're fighting against these things isn't it?
" and all cells have only so much resources and limited ability to replenish them. "
I think this is really insightful, and a key maybe to developing new treatments?
I will look into the daptomycin trials, seems really interesting!
Oh by the way, I changed the title of this thread to include antibiotics and herbs.
For some reason it only changes it on the front page's list of threads though, not when you click on it.
Oh well, I tried haha.