ref - inflammation
perhaps some of the apparent contradictions come from differences between what your PCP might regard as inflammation and what people with chronic illnesses might consider inflammation
if you go to your PCP/GP and complain of lots of weird symptoms - swollen joints, fatigue, circulation problems, sore head, neck, pain everywhere - they will likely run a standard panel of basic cheap tests including
-complete blood count,
-Sedimentation rate (ESR)
-c-reactive protein (CRP)
maybe Liver Functions and a couple of others depending on exact symptoms you give
and these will, even in quite sick chronic Lyme patients with swollen joints ( ie obvious tissue inflammation), come back within the normal range. And the modern conventional PCP will then tell you that despite the swollen joints and abnormal symptoms - "your labs are normal - and you don't have inflammation and therefore you cant have an active infection either because if you did the CRP and ESR would both be raised - so basically go home and stop bothering us"
however, a very small amount of googling about
any of the chronic bacterial infections we are concerned about
here, Lyme, bartonella, mycoplasma etc etc will show that the research completely contradicts what the PCP just told you and in more than 50% of cases with these illnesses - CRP and ESR can often be within the normal range - mine always is.
in addition when tested for other markers of inflammation - my test results were often sky high
-on stool tests secretory IgA would be through the roof, calprotectin, lactoferrin also
-on OAT tests - markers for inflammation were up to 10x the normal range.
-other surrogate markers for inflammation were also present
--25-vitamin D / 25-OH vitamin D ratio out of balance - known to be driven by inflammation
--T3vs RevT3 ratio out of balance - again driven by inflammation
so, in essence, whilst i agree inflammation has become a kind of buzzword in functional medicine, there absolutely is evidence of inflammation in chronic illnesses - but its just not reflected in the very basic testing primary care doctors use to diagnose acute inflammation in acute illnesses - because those markers are actually often suppressed by chronic infection and possibly in other chronic illness states.
however, if you read the literature on the causal mechanisms of just about
every chronic disease known to man you will find inflammatory mechanisms at the root of them.
e.g. coronary heart disease, COPD, type 2 diabetes etc etc
perhaps some general scepticism is also driven by the fact that whilst it might be relatively easy to identify the causal mechanism of many of these chronic illnesses in research - actually turning around these mechanism in real patients, after perhaps 20-30 years of disease processes, is a far harder tasks - that is rarely as simple as "just take this pill 2x a day" that most people would like and have become accustomed to - and that perhaps leads to additional doubt and dissatisfaction with the science.
Post Edited (Garzie) : 11/29/2021 3:50:41 AM (GMT-7)