In no particular order:
Relationships- family, friends and spouses at times feel helpless and distance themselves because they do not understand as well as the ones who don't seem to care or have any desire to understand and learn more. Then guilt comes as a result of relationships falling apart.
Finances- finding medications, treatments and physicians are all very costly, as well as affecting a job/career and the ability to be there, much less move up the "food chain"
Jobs/Hobbies- it is hard to do ANYTHING when migraines take over your life. Losing jobs is difficult because again, that ties in to money and relationships as well. Losing hobbies puts things into perspective...How bad is it that I can't do things I (used to) enjoy?
I think, for most, there is less fear and anxiety about having migraines in general BUT it's more of a "when are they going to hit?" I am engaged and have been terrified that I will have a "bad one" on my wedding day.
Medications/Treatments/Triggers- I have found that taking different medications and treatments is hard on your body in general. Starting and stopping medications, losing and gaining weight, side effects from each thing. AND Finding triggers..wow, that one is fun. How many diaries have I been through? ha ha
If I had to pick ONE thing, I would have to say that my finances in general have suffered more than anything. I had hit rock bottom at one point and lost everything, I am still trying to dig out of medical bills and probably will for some time to come.
I hope this helps!