Posted 3/22/2008 5:24 PM (GMT -7)
Thanks for the post Ann, a very important topic indeed. Just two things I wanted to mention:
1) I'm not especially knowledgeable concerning Cluster Headache sufferers, but why is it that they are less prone to rebound? I have never heard of this, though I am no expert.
Also, I think that there are reasons that triptans are only supposed to be taken 2-3 times a week max aside from rebound risks. All of the detailed prescribing information that I've read about many triptans has stated this type of limit without noting any kind of exception (other than by express doctor's orders, but I think that they would only order more frequent use for a very short term acute treatment).
2) It's definitely important to not take more than 2 doses/24 hours (unless your doctor says otherwise). One thing that I didn't initially know, however, is that it's also unsafe to use any ergotamine derivatives (like Cafergot and DHE) during the same day as a triptan. This is also due to the potential cardiovascular risk.